Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma

The ability to utilize preclinical models to predict the clinical toxicity of chimeric antigen receptor (CAR) T cells in solid tumors is tenuous, thereby necessitating the development and evaluation of gated systems. Here we found that murine GD2 CAR-T cells, specific for the tumor-associated antige...

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Detalles Bibliográficos
Autores principales: Moghimi, Babak, Muthugounder, Sakunthala, Jambon, Samy, Tibbetts, Rachelle, Hung, Long, Bassiri, Hamid, Hogarty, Michael D., Barrett, David M., Shimada, Hiroyuki, Asgharzadeh, Shahab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820416/
https://www.ncbi.nlm.nih.gov/pubmed/33479234
http://dx.doi.org/10.1038/s41467-020-20785-x

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