SERCA2a ameliorates cardiomyocyte T-tubule remodeling via the calpain/JPH2 pathway to improve cardiac function in myocardial ischemia/reperfusion mice

Transverse-tubules (T-tubules) play pivotal roles in Ca(2+)-induced, Ca(2+) release and excitation–contraction coupling in cardiomyocytes. The purpose of this study was to uncover mechanisms where sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA2a) improved cardiac function through T-tubule regulati...

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Detalles Bibliográficos
Autores principales: Wang, Shuai, Zhou, You, Luo, Yuanyuan, Kan, Rongsheng, Chen, Jingwen, Xuan, Haochen, Wang, Chaofan, Chen, Junhong, Xu, Tongda, Li, Dongye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820433/
https://www.ncbi.nlm.nih.gov/pubmed/33479390
http://dx.doi.org/10.1038/s41598-021-81570-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820433/
https://www.ncbi.nlm.nih.gov/pubmed/33479390
http://dx.doi.org/10.1038/s41598-021-81570-4

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