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Fibroblast growth factor receptor facilitates recurrence of minimal residual disease following trastuzumab emtansine therapy

Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate (ADC) that efficiently delivers a highly potent microtubule inhibitor to HER2 overexpressing cells. Herein, we utilize HER2 transformed human mammary epithelial cells (HME2) to demonstrate in vitro and in vivo response and recurrence upon T...

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Detalles Bibliográficos
Autores principales:	Akhand, Saeed S., Chen, Hao, Purdy, Stephen Connor, Liu, Zian, Anderson, Joshua C., Willey, Christopher D., Wendt, Michael K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820437/ https://www.ncbi.nlm.nih.gov/pubmed/33479246 http://dx.doi.org/10.1038/s41523-020-00213-5

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