SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan

Missense mutations in Valosin-Containing Protein (VCP) are linked to diverse degenerative diseases including IBMPFD, amyotrophic lateral sclerosis (ALS), muscular dystrophy and Parkinson’s disease. Here, we characterize a VCP-binding co-factor (SVIP) that specifically recruits VCP to lysosomes. SVIP...

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Detalles Bibliográficos
Autores principales: Johnson, Alyssa E., Orr, Brian O., Fetter, Richard D., Moughamian, Armen J., Primeaux, Logan A., Geier, Ethan G., Yokoyama, Jennifer S., Miller, Bruce L., Davis, Graeme W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820495/
https://www.ncbi.nlm.nih.gov/pubmed/33479240
http://dx.doi.org/10.1038/s41467-020-20796-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820495/
https://www.ncbi.nlm.nih.gov/pubmed/33479240
http://dx.doi.org/10.1038/s41467-020-20796-8

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