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Short-term cardiac outcome in survivors of COVID-19: a systematic study after hospital discharge

BACKGROUND: COVID-19 has caused considerable morbidity and mortality worldwide and cardiac involvement has been reported during infection. The short-term cardiac outcome in survivors of COVID-19 is not known. OBJECTIVE: To examine the heart of patients who survived COVID-19 and to compare the cardia...

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Autores principales: Sechi, Leonardo A., Colussi, Gianluca, Bulfone, Luca, Brosolo, Gabriele, Da Porto, Andrea, Peghin, Maddalena, Patruno, Vincenzo, Tascini, Carlo, Catena, Cristiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820534/
https://www.ncbi.nlm.nih.gov/pubmed/33481096
http://dx.doi.org/10.1007/s00392-020-01800-z
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author Sechi, Leonardo A.
Colussi, Gianluca
Bulfone, Luca
Brosolo, Gabriele
Da Porto, Andrea
Peghin, Maddalena
Patruno, Vincenzo
Tascini, Carlo
Catena, Cristiana
author_facet Sechi, Leonardo A.
Colussi, Gianluca
Bulfone, Luca
Brosolo, Gabriele
Da Porto, Andrea
Peghin, Maddalena
Patruno, Vincenzo
Tascini, Carlo
Catena, Cristiana
author_sort Sechi, Leonardo A.
collection PubMed
description BACKGROUND: COVID-19 has caused considerable morbidity and mortality worldwide and cardiac involvement has been reported during infection. The short-term cardiac outcome in survivors of COVID-19 is not known. OBJECTIVE: To examine the heart of patients who survived COVID-19 and to compare the cardiac outcome between patients who recovered from mild-to-moderate or severe illness. METHODS: With use of ECG and echocardiography, we examined the heart of 105 patients who had been hospitalized with COVID-19 and were consecutively recruited after hospital discharge while attending follow-up visits. Survivors of COVID-19 were compared with 105 matched controls. We also compared the cardiac outcome and lung ultrasound scan between COVID-19 patients who had mild-to-moderate or severe illness. RESULTS: Cardiac data were collected a median of 41 days from the first detection of COVID-19. Symptoms were present in a low percentage of patients. In comparison with matched controls, no considerable structural or functional differences were observed in the heart of survivors of COVID-19. Lung ultrasound scan detected significantly greater residual pulmonary involvement in COVID-19 patients who had recovered from severe than mild-to-moderate illness. No significant differences were detected in ECG tracings nor were found in the left and right ventricular function of patients who had recovered from mild-to-moderate or severe illness. CONCLUSIONS: In a short-term follow-up, no abnormalities were identified in the heart of survivors of COVID-19, nor cardiac differences were detected between patients who had different severity of illness. With the limitations of a cross-sectional study, these findings suggest that patients who recover from COVID-19 do not have considerable cardiac sequelae. GRAPHIC ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00392-020-01800-z.
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spelling pubmed-78205342021-01-22 Short-term cardiac outcome in survivors of COVID-19: a systematic study after hospital discharge Sechi, Leonardo A. Colussi, Gianluca Bulfone, Luca Brosolo, Gabriele Da Porto, Andrea Peghin, Maddalena Patruno, Vincenzo Tascini, Carlo Catena, Cristiana Clin Res Cardiol Original Paper BACKGROUND: COVID-19 has caused considerable morbidity and mortality worldwide and cardiac involvement has been reported during infection. The short-term cardiac outcome in survivors of COVID-19 is not known. OBJECTIVE: To examine the heart of patients who survived COVID-19 and to compare the cardiac outcome between patients who recovered from mild-to-moderate or severe illness. METHODS: With use of ECG and echocardiography, we examined the heart of 105 patients who had been hospitalized with COVID-19 and were consecutively recruited after hospital discharge while attending follow-up visits. Survivors of COVID-19 were compared with 105 matched controls. We also compared the cardiac outcome and lung ultrasound scan between COVID-19 patients who had mild-to-moderate or severe illness. RESULTS: Cardiac data were collected a median of 41 days from the first detection of COVID-19. Symptoms were present in a low percentage of patients. In comparison with matched controls, no considerable structural or functional differences were observed in the heart of survivors of COVID-19. Lung ultrasound scan detected significantly greater residual pulmonary involvement in COVID-19 patients who had recovered from severe than mild-to-moderate illness. No significant differences were detected in ECG tracings nor were found in the left and right ventricular function of patients who had recovered from mild-to-moderate or severe illness. CONCLUSIONS: In a short-term follow-up, no abnormalities were identified in the heart of survivors of COVID-19, nor cardiac differences were detected between patients who had different severity of illness. With the limitations of a cross-sectional study, these findings suggest that patients who recover from COVID-19 do not have considerable cardiac sequelae. GRAPHIC ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00392-020-01800-z. Springer Berlin Heidelberg 2021-01-22 2021 /pmc/articles/PMC7820534/ /pubmed/33481096 http://dx.doi.org/10.1007/s00392-020-01800-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Sechi, Leonardo A.
Colussi, Gianluca
Bulfone, Luca
Brosolo, Gabriele
Da Porto, Andrea
Peghin, Maddalena
Patruno, Vincenzo
Tascini, Carlo
Catena, Cristiana
Short-term cardiac outcome in survivors of COVID-19: a systematic study after hospital discharge
title Short-term cardiac outcome in survivors of COVID-19: a systematic study after hospital discharge
title_full Short-term cardiac outcome in survivors of COVID-19: a systematic study after hospital discharge
title_fullStr Short-term cardiac outcome in survivors of COVID-19: a systematic study after hospital discharge
title_full_unstemmed Short-term cardiac outcome in survivors of COVID-19: a systematic study after hospital discharge
title_short Short-term cardiac outcome in survivors of COVID-19: a systematic study after hospital discharge
title_sort short-term cardiac outcome in survivors of covid-19: a systematic study after hospital discharge
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820534/
https://www.ncbi.nlm.nih.gov/pubmed/33481096
http://dx.doi.org/10.1007/s00392-020-01800-z
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