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Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release
The story of human dreams about curing all diseases, disorders and lesions is as old as human history. In the frontier of medical science, nanomedicine is trying to solve the problem. In this study, inspired by nanotechnology and using “grafting from” approach, a novel lignin-based nanogel was synth...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820611/ https://www.ncbi.nlm.nih.gov/pubmed/33479381 http://dx.doi.org/10.1038/s41598-021-81393-3 |
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author | Dinari, Ali Abdollahi, Mahdi Sadeghizadeh, Majid |
author_facet | Dinari, Ali Abdollahi, Mahdi Sadeghizadeh, Majid |
author_sort | Dinari, Ali |
collection | PubMed |
description | The story of human dreams about curing all diseases, disorders and lesions is as old as human history. In the frontier of medical science, nanomedicine is trying to solve the problem. In this study, inspired by nanotechnology and using “grafting from” approach, a novel lignin-based nanogel was synthesized using atom transfer radical polymerization (ATRP) method. N-isopropylacrylamide (NIPAM) and N,N-dimethylaminoethylmethacrylate (DMAEMA) comonomers were graft copolymerized from fully brominated lignin as ATRP macroinitiator to synthesize lignin-g-P(NIPAM-co-DMAEMA) nanogel (LNDNG). By controlling the initial comonomer compositions and ATRP conditions, four LNDNG systems with different lower critical solution temperatures (LCSTs) of 32, 34, 37 and 42 °C were prepared. The LNDNGs were evaluated by GPC, FT-IR, (1)H NMR, UV–Vis, DLS, SEM and TEM analyses. The prepared nanogels exhibited an average diameter of 150 nm with dual temperature and pH responsiveness. Curcumin (CUR) loading capacity and encapsulation efficiency of the LNDNGs were 49.69% and 92.62% on average, respectively. The cumulative release amount of loaded CUR was observed to be 65.36% after 72 h. The new lignin-based NGs proposed in the present work seems to be a promising, safe and comparable system in a near future. |
format | Online Article Text |
id | pubmed-7820611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78206112021-01-26 Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release Dinari, Ali Abdollahi, Mahdi Sadeghizadeh, Majid Sci Rep Article The story of human dreams about curing all diseases, disorders and lesions is as old as human history. In the frontier of medical science, nanomedicine is trying to solve the problem. In this study, inspired by nanotechnology and using “grafting from” approach, a novel lignin-based nanogel was synthesized using atom transfer radical polymerization (ATRP) method. N-isopropylacrylamide (NIPAM) and N,N-dimethylaminoethylmethacrylate (DMAEMA) comonomers were graft copolymerized from fully brominated lignin as ATRP macroinitiator to synthesize lignin-g-P(NIPAM-co-DMAEMA) nanogel (LNDNG). By controlling the initial comonomer compositions and ATRP conditions, four LNDNG systems with different lower critical solution temperatures (LCSTs) of 32, 34, 37 and 42 °C were prepared. The LNDNGs were evaluated by GPC, FT-IR, (1)H NMR, UV–Vis, DLS, SEM and TEM analyses. The prepared nanogels exhibited an average diameter of 150 nm with dual temperature and pH responsiveness. Curcumin (CUR) loading capacity and encapsulation efficiency of the LNDNGs were 49.69% and 92.62% on average, respectively. The cumulative release amount of loaded CUR was observed to be 65.36% after 72 h. The new lignin-based NGs proposed in the present work seems to be a promising, safe and comparable system in a near future. Nature Publishing Group UK 2021-01-21 /pmc/articles/PMC7820611/ /pubmed/33479381 http://dx.doi.org/10.1038/s41598-021-81393-3 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Dinari, Ali Abdollahi, Mahdi Sadeghizadeh, Majid Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release |
title | Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release |
title_full | Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release |
title_fullStr | Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release |
title_full_unstemmed | Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release |
title_short | Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release |
title_sort | design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820611/ https://www.ncbi.nlm.nih.gov/pubmed/33479381 http://dx.doi.org/10.1038/s41598-021-81393-3 |
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