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Role of tenofovir disoproxil fumarate in prevention of perinatal transmission of hepatitis B virus from mother to child: a systematic review and meta-analysis

BACKGROUND/AIMS: To prevent the perinatal transmission of hepatitis B virus (HBV) from mother to child, administration of an antiviral agent during pregnancy has been attempted in women who are either hepatitis B e antigen positive or have a high viral load. In this systematic review and meta-analys...

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Autores principales: Lee, Young-Sun, Lee, Ha Seok, Kim, Ji Hoon, Chang, Sung Won, Hyun, Myung Han, Bak, Haein, Kim, Sehwa, Lee, Min-jin, Lee, Chan Uk, Jung, Young Kul, Seo, Yeon Seok, Yim, Hyung Joon, Yeon, Jong Eun, Um, Soon Ho, Byun, Kwan Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820648/
https://www.ncbi.nlm.nih.gov/pubmed/31878771
http://dx.doi.org/10.3904/kjim.2018.465
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author Lee, Young-Sun
Lee, Ha Seok
Kim, Ji Hoon
Chang, Sung Won
Hyun, Myung Han
Bak, Haein
Kim, Sehwa
Lee, Min-jin
Lee, Chan Uk
Jung, Young Kul
Seo, Yeon Seok
Yim, Hyung Joon
Yeon, Jong Eun
Um, Soon Ho
Byun, Kwan Soo
author_facet Lee, Young-Sun
Lee, Ha Seok
Kim, Ji Hoon
Chang, Sung Won
Hyun, Myung Han
Bak, Haein
Kim, Sehwa
Lee, Min-jin
Lee, Chan Uk
Jung, Young Kul
Seo, Yeon Seok
Yim, Hyung Joon
Yeon, Jong Eun
Um, Soon Ho
Byun, Kwan Soo
author_sort Lee, Young-Sun
collection PubMed
description BACKGROUND/AIMS: To prevent the perinatal transmission of hepatitis B virus (HBV) from mother to child, administration of an antiviral agent during pregnancy has been attempted in women who are either hepatitis B e antigen positive or have a high viral load. In this systematic review and meta-analysis with randomized controlled trials, we analyzed the efficacy and safety of tenofovir disoproxil fumarate (TDF) in preventing the perinatal transmission of HBV in pregnant women who have high HBV DNA titers. METHODS: Multiple comprehensive databases (PubMed, EMBASE, and Cochrane databases) were searched for studies evaluating the efficacy of TDF for the prevention of perinatal transmission of HBV. RESULTS: Two studies (one open label study and one double blind study) were included and analyzed. Intention-to-treat analysis (527 pregnancies) showed that the preventive effect of TDF was not significant (odds ratio [OR], 0.53; 95% confidence interval [CI], 0.13 to 2.17; p = 0.38, I(2) = 81%). However, the per-protocol analysis showed that TDF significantly reduced perinatal transmission (OR, 0.10; 95% CI, 0.01 to 0.77; p = 0.03, I(2) = 0%). There was no significant difference between the TDF group and the control group with respect to maternal and fetal safety outcomes. CONCLUSIONS: In pregnant women who have high HBV DNA titers, TDF can reduce the perinatal transmission from mother to child without significant adverse events.
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spelling pubmed-78206482021-01-27 Role of tenofovir disoproxil fumarate in prevention of perinatal transmission of hepatitis B virus from mother to child: a systematic review and meta-analysis Lee, Young-Sun Lee, Ha Seok Kim, Ji Hoon Chang, Sung Won Hyun, Myung Han Bak, Haein Kim, Sehwa Lee, Min-jin Lee, Chan Uk Jung, Young Kul Seo, Yeon Seok Yim, Hyung Joon Yeon, Jong Eun Um, Soon Ho Byun, Kwan Soo Korean J Intern Med Original Article BACKGROUND/AIMS: To prevent the perinatal transmission of hepatitis B virus (HBV) from mother to child, administration of an antiviral agent during pregnancy has been attempted in women who are either hepatitis B e antigen positive or have a high viral load. In this systematic review and meta-analysis with randomized controlled trials, we analyzed the efficacy and safety of tenofovir disoproxil fumarate (TDF) in preventing the perinatal transmission of HBV in pregnant women who have high HBV DNA titers. METHODS: Multiple comprehensive databases (PubMed, EMBASE, and Cochrane databases) were searched for studies evaluating the efficacy of TDF for the prevention of perinatal transmission of HBV. RESULTS: Two studies (one open label study and one double blind study) were included and analyzed. Intention-to-treat analysis (527 pregnancies) showed that the preventive effect of TDF was not significant (odds ratio [OR], 0.53; 95% confidence interval [CI], 0.13 to 2.17; p = 0.38, I(2) = 81%). However, the per-protocol analysis showed that TDF significantly reduced perinatal transmission (OR, 0.10; 95% CI, 0.01 to 0.77; p = 0.03, I(2) = 0%). There was no significant difference between the TDF group and the control group with respect to maternal and fetal safety outcomes. CONCLUSIONS: In pregnant women who have high HBV DNA titers, TDF can reduce the perinatal transmission from mother to child without significant adverse events. The Korean Association of Internal Medicine 2021-01 2019-12-31 /pmc/articles/PMC7820648/ /pubmed/31878771 http://dx.doi.org/10.3904/kjim.2018.465 Text en Copyright © 2021 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Young-Sun
Lee, Ha Seok
Kim, Ji Hoon
Chang, Sung Won
Hyun, Myung Han
Bak, Haein
Kim, Sehwa
Lee, Min-jin
Lee, Chan Uk
Jung, Young Kul
Seo, Yeon Seok
Yim, Hyung Joon
Yeon, Jong Eun
Um, Soon Ho
Byun, Kwan Soo
Role of tenofovir disoproxil fumarate in prevention of perinatal transmission of hepatitis B virus from mother to child: a systematic review and meta-analysis
title Role of tenofovir disoproxil fumarate in prevention of perinatal transmission of hepatitis B virus from mother to child: a systematic review and meta-analysis
title_full Role of tenofovir disoproxil fumarate in prevention of perinatal transmission of hepatitis B virus from mother to child: a systematic review and meta-analysis
title_fullStr Role of tenofovir disoproxil fumarate in prevention of perinatal transmission of hepatitis B virus from mother to child: a systematic review and meta-analysis
title_full_unstemmed Role of tenofovir disoproxil fumarate in prevention of perinatal transmission of hepatitis B virus from mother to child: a systematic review and meta-analysis
title_short Role of tenofovir disoproxil fumarate in prevention of perinatal transmission of hepatitis B virus from mother to child: a systematic review and meta-analysis
title_sort role of tenofovir disoproxil fumarate in prevention of perinatal transmission of hepatitis b virus from mother to child: a systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820648/
https://www.ncbi.nlm.nih.gov/pubmed/31878771
http://dx.doi.org/10.3904/kjim.2018.465
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