Targeting the Endothelin-1 Receptors Curtails Tumor Growth and Angiogenesis in Multiple Myeloma

The endothelin-1 (ET-1) receptors were recently found to mediate pro-survival functions in multiple myeloma (MM) cells in response to autocrine ET-1. This study investigated the effectiveness of macitentan, a dual ET-1 receptor antagonist, in MM treatment, and the mechanisms underlying its activitie...

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Detalles Bibliográficos
Autores principales: Russignan, Anna, Dal Collo, Giada, Bagnato, Anna, Tamassia, Nicola, Bugatti, Mattia, Belleri, Mirella, Lorenzi, Luisa, Borsi, Enrica, Bazzoni, Riccardo, Gottardi, Michele, Terragna, Carolina, Vermi, William, Giacomini, Arianna, Presta, Marco, Cassatella, Marco Antonio, Krampera, Mauro, Tecchio, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820698/
https://www.ncbi.nlm.nih.gov/pubmed/33489901
http://dx.doi.org/10.3389/fonc.2020.600025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820698/
https://www.ncbi.nlm.nih.gov/pubmed/33489901
http://dx.doi.org/10.3389/fonc.2020.600025

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