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Targeting the Endothelin-1 Receptors Curtails Tumor Growth and Angiogenesis in Multiple Myeloma
The endothelin-1 (ET-1) receptors were recently found to mediate pro-survival functions in multiple myeloma (MM) cells in response to autocrine ET-1. This study investigated the effectiveness of macitentan, a dual ET-1 receptor antagonist, in MM treatment, and the mechanisms underlying its activitie...
Autores principales: | Russignan, Anna, Dal Collo, Giada, Bagnato, Anna, Tamassia, Nicola, Bugatti, Mattia, Belleri, Mirella, Lorenzi, Luisa, Borsi, Enrica, Bazzoni, Riccardo, Gottardi, Michele, Terragna, Carolina, Vermi, William, Giacomini, Arianna, Presta, Marco, Cassatella, Marco Antonio, Krampera, Mauro, Tecchio, Cristina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820698/ https://www.ncbi.nlm.nih.gov/pubmed/33489901 http://dx.doi.org/10.3389/fonc.2020.600025 |
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