Conformational Ensembles of Antibodies Determine Their Hydrophobicity

A major challenge in the development of antibody biotherapeutics is their tendency to aggregate. One root cause for aggregation is exposure of hydrophobic surface regions to the solvent. Many current techniques predict the relative aggregation propensity of antibodies via precalculated scales for th...

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Detalles Bibliográficos
Autores principales: Waibl, Franz, Fernández-Quintero, Monica L., Kamenik, Anna S., Kraml, Johannes, Hofer, Florian, Kettenberger, Hubert, Georges, Guy, Liedl, Klaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820740/
https://www.ncbi.nlm.nih.gov/pubmed/33220303
http://dx.doi.org/10.1016/j.bpj.2020.11.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820740/
https://www.ncbi.nlm.nih.gov/pubmed/33220303
http://dx.doi.org/10.1016/j.bpj.2020.11.010

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