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Persistently higher serum sCD40L levels are associated with outcome in septic patients

BACKGROUND: Soluble CD40 ligand (sCD40L) exhibits proinflammatory and procoagulant effects. Recent data indicated that sCD40L plays a significant role in septic patients. The aim of the present study was to determine sCD40L changes in surgical patients without sepsis (SWS) and surgical sepsis patien...

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Autores principales: Liang, Yingjian, Zhu, Chengrui, Sun, Yini, Li, Zhiliang, Wang, Liang, Liu, Yina, Li, Xin, Ma, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820820/
https://www.ncbi.nlm.nih.gov/pubmed/33482737
http://dx.doi.org/10.1186/s12871-021-01241-9
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author Liang, Yingjian
Zhu, Chengrui
Sun, Yini
Li, Zhiliang
Wang, Liang
Liu, Yina
Li, Xin
Ma, Xiaochun
author_facet Liang, Yingjian
Zhu, Chengrui
Sun, Yini
Li, Zhiliang
Wang, Liang
Liu, Yina
Li, Xin
Ma, Xiaochun
author_sort Liang, Yingjian
collection PubMed
description BACKGROUND: Soluble CD40 ligand (sCD40L) exhibits proinflammatory and procoagulant effects. Recent data indicated that sCD40L plays a significant role in septic patients. The aim of the present study was to determine sCD40L changes in surgical patients without sepsis (SWS) and surgical sepsis patients (SS) during the first 3 days after intensive care unit (ICU) admission and to observe the association between sCD40L and mortality. METHODS: Time changes in sCD40L levels were assessed for 3 days after ICU admission in 49 patients with SS and compared with those in 19 SWS patients. Serum sCD40L concentration was detected by ELISA. Survival at 28 days served as the endpoint. RESULTS: SS had significantly higher sCD40L levels than SWS and control patients. We observed an association between sCD40L levels ≥1028.75 pg/mL at day 2 and 28-day mortality (odds ratio = 7.888; 95% confidence interval = 1.758 to 35.395; P = 0.007). We could not discover any significant differences in sex, presence of septic shock, site of infection, length of stay in the ICU, PaO(2)/FiO(2) ratio, incidence of AKI, ARDS, or type of surgery between nonsurvivors and survivors. CONCLUSIONS: Septic patients show persistently higher circulating sCD40L levels in the first 3 days after ICU admission, and serum sCD40L levels are associated with the mortality of patients with sepsis. Thus, serum sCD40L may be used as a reliable biomarker and therapeutic target in sepsis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12871-021-01241-9.
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spelling pubmed-78208202021-01-22 Persistently higher serum sCD40L levels are associated with outcome in septic patients Liang, Yingjian Zhu, Chengrui Sun, Yini Li, Zhiliang Wang, Liang Liu, Yina Li, Xin Ma, Xiaochun BMC Anesthesiol Research Article BACKGROUND: Soluble CD40 ligand (sCD40L) exhibits proinflammatory and procoagulant effects. Recent data indicated that sCD40L plays a significant role in septic patients. The aim of the present study was to determine sCD40L changes in surgical patients without sepsis (SWS) and surgical sepsis patients (SS) during the first 3 days after intensive care unit (ICU) admission and to observe the association between sCD40L and mortality. METHODS: Time changes in sCD40L levels were assessed for 3 days after ICU admission in 49 patients with SS and compared with those in 19 SWS patients. Serum sCD40L concentration was detected by ELISA. Survival at 28 days served as the endpoint. RESULTS: SS had significantly higher sCD40L levels than SWS and control patients. We observed an association between sCD40L levels ≥1028.75 pg/mL at day 2 and 28-day mortality (odds ratio = 7.888; 95% confidence interval = 1.758 to 35.395; P = 0.007). We could not discover any significant differences in sex, presence of septic shock, site of infection, length of stay in the ICU, PaO(2)/FiO(2) ratio, incidence of AKI, ARDS, or type of surgery between nonsurvivors and survivors. CONCLUSIONS: Septic patients show persistently higher circulating sCD40L levels in the first 3 days after ICU admission, and serum sCD40L levels are associated with the mortality of patients with sepsis. Thus, serum sCD40L may be used as a reliable biomarker and therapeutic target in sepsis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12871-021-01241-9. BioMed Central 2021-01-22 /pmc/articles/PMC7820820/ /pubmed/33482737 http://dx.doi.org/10.1186/s12871-021-01241-9 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Liang, Yingjian
Zhu, Chengrui
Sun, Yini
Li, Zhiliang
Wang, Liang
Liu, Yina
Li, Xin
Ma, Xiaochun
Persistently higher serum sCD40L levels are associated with outcome in septic patients
title Persistently higher serum sCD40L levels are associated with outcome in septic patients
title_full Persistently higher serum sCD40L levels are associated with outcome in septic patients
title_fullStr Persistently higher serum sCD40L levels are associated with outcome in septic patients
title_full_unstemmed Persistently higher serum sCD40L levels are associated with outcome in septic patients
title_short Persistently higher serum sCD40L levels are associated with outcome in septic patients
title_sort persistently higher serum scd40l levels are associated with outcome in septic patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820820/
https://www.ncbi.nlm.nih.gov/pubmed/33482737
http://dx.doi.org/10.1186/s12871-021-01241-9
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