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Engineering of Humanized Antibodies Against Human Interleukin 5 Receptor Alpha Subunit That Cause Potent Antibody-Dependent Cell-Mediated Cytotoxicity

Patients with severe eosinophilic asthma (SEA; characterized by persistent eosinophilia in blood and airway tissues) experience frequent asthma exacerbations with poor clinical outcomes. Interleukin 5 (IL-5) and IL-5 receptor alpha subunit (IL-5α) play key roles in eosinophilia maintenance, and rele...

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Detalles Bibliográficos
Autores principales:	Kim, Jung-Eun, Lee, Dong-Hyun, Jung, Keunok, Kim, Eun-Ji, Choi, Youngwoo, Park, Hae-Sim, Kim, Yong-Sung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820887/ https://www.ncbi.nlm.nih.gov/pubmed/33488590 http://dx.doi.org/10.3389/fimmu.2020.593748

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