Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program

BACKGROUND: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). METHODS: We followed 5743 OSCCs between 2004 and 2009 from a population‐based screening program and ascertained death until the end of 2012. RESULTS: The hazard ratios (HRs) of mortality from OSCC we...

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Detalles Bibliográficos
Autores principales: Su, William Wang‐Yu, Lee, Yi‐Huah, Yen, Amy Ming‐Fang, Chen, Sam Li‐Sheng, Hsu, Chen‐Yang, Chiu, Sherry Yueh‐Hsia, Fann, Jean Ching‐Yuan, Lee, Yi‐Chia, Chiu, Han‐Mo, Hsiao, Shu‐Chun, Hsu, Tsui‐Hsia, Chen, Hsiu‐Hsi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820997/
https://www.ncbi.nlm.nih.gov/pubmed/33047420
http://dx.doi.org/10.1002/hed.26504
Descripción
Sumario:BACKGROUND: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). METHODS: We followed 5743 OSCCs between 2004 and 2009 from a population‐based screening program and ascertained death until the end of 2012. RESULTS: The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30‐1.65) and 1.18 (1.04‐1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01‐1.24) and 1.00 (0.91‐1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P < .05). However, treatment at medical center had a lower mortality (0.83, 0.75‐0.91) than local/regional hospital. CONCLUSIONS: Treatment delay longer than 6 weeks for OSCCs detected via a population‐based screening program had unfavorable survival.

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