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Overview of Biologically Active Nucleoside Phosphonates

The use of the phosphonate motif featuring a carbon-phosphorous bond as bioisosteric replacement of the labile P–O bond is widely recognized as an attractive structural concept in different areas of medicinal chemistry, since it addresses the very fundamental principles of enzymatic stability and mi...

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Detalles Bibliográficos
Autores principales: Groaz, Elisabetta, De Jonghe, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821050/
https://www.ncbi.nlm.nih.gov/pubmed/33490040
http://dx.doi.org/10.3389/fchem.2020.616863