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Risk factors for the COVID‐19 severity and its correlation with viral shedding: A retrospective cohort study
Coronavirus disease 2019 (COVID‐19) have become a pandemic in the world. This study is aim to explore risk factors for COVID‐19 severity in the early stage and the correlation between the viral shedding and COVID‐19 severity. We included inpatient with laboratory confirmed COVID‐19 who had been disc...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821149/ https://www.ncbi.nlm.nih.gov/pubmed/32725915 http://dx.doi.org/10.1002/jmv.26367 |
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author | Zheng, Xinchun Chen, Jiehua Deng, Lisi Fang, Zhaoxiong Chen, Gongqi Ye, Di Xia, Jinyu Hong, Zhongsi |
author_facet | Zheng, Xinchun Chen, Jiehua Deng, Lisi Fang, Zhaoxiong Chen, Gongqi Ye, Di Xia, Jinyu Hong, Zhongsi |
author_sort | Zheng, Xinchun |
collection | PubMed |
description | Coronavirus disease 2019 (COVID‐19) have become a pandemic in the world. This study is aim to explore risk factors for COVID‐19 severity in the early stage and the correlation between the viral shedding and COVID‐19 severity. We included inpatient with laboratory confirmed COVID‐19 who had been discharged by 9 March 2020. The medical record data and dynamic change of biochemical indicators in‐hospital were compared between common and severe patients. Eighty patients were included in this study. Multivariable regression demonstrated increasing odds of severity associated with the duration of fever (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.10‐1.82, per day increase; P = .007), C‐reactive protein (CRP) (OR, 1.26; 95% CI, 1.04‐1.52; P = .02), and PO(2) < 80 mm Hg (28.07, 95% CI, 1.50‐524.12; P = .026) on admission. We found severe acute respiratory syndrome coronavirus 2 viral RNA could be long‐term presence in respiratory tract and fecal sample, up to 43 and 46 days, respectively. However, the duration of viral shedding have no correlation with the COVID‐19 severity. The duration of fever, elevated CRP and PO(2) < 80 mm Hg on admission were associated with the COVID‐19 severity in the early stage and there is no correlation between the viral shedding and COVID‐19 severity. |
format | Online Article Text |
id | pubmed-7821149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78211492021-01-26 Risk factors for the COVID‐19 severity and its correlation with viral shedding: A retrospective cohort study Zheng, Xinchun Chen, Jiehua Deng, Lisi Fang, Zhaoxiong Chen, Gongqi Ye, Di Xia, Jinyu Hong, Zhongsi J Med Virol Research Articles Coronavirus disease 2019 (COVID‐19) have become a pandemic in the world. This study is aim to explore risk factors for COVID‐19 severity in the early stage and the correlation between the viral shedding and COVID‐19 severity. We included inpatient with laboratory confirmed COVID‐19 who had been discharged by 9 March 2020. The medical record data and dynamic change of biochemical indicators in‐hospital were compared between common and severe patients. Eighty patients were included in this study. Multivariable regression demonstrated increasing odds of severity associated with the duration of fever (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.10‐1.82, per day increase; P = .007), C‐reactive protein (CRP) (OR, 1.26; 95% CI, 1.04‐1.52; P = .02), and PO(2) < 80 mm Hg (28.07, 95% CI, 1.50‐524.12; P = .026) on admission. We found severe acute respiratory syndrome coronavirus 2 viral RNA could be long‐term presence in respiratory tract and fecal sample, up to 43 and 46 days, respectively. However, the duration of viral shedding have no correlation with the COVID‐19 severity. The duration of fever, elevated CRP and PO(2) < 80 mm Hg on admission were associated with the COVID‐19 severity in the early stage and there is no correlation between the viral shedding and COVID‐19 severity. John Wiley and Sons Inc. 2020-09-16 2021-02 /pmc/articles/PMC7821149/ /pubmed/32725915 http://dx.doi.org/10.1002/jmv.26367 Text en © 2020 The Authors. Journal of Medical Virology Published by Wiley Periodicals LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Zheng, Xinchun Chen, Jiehua Deng, Lisi Fang, Zhaoxiong Chen, Gongqi Ye, Di Xia, Jinyu Hong, Zhongsi Risk factors for the COVID‐19 severity and its correlation with viral shedding: A retrospective cohort study |
title | Risk factors for the COVID‐19 severity and its correlation with viral shedding: A retrospective cohort study |
title_full | Risk factors for the COVID‐19 severity and its correlation with viral shedding: A retrospective cohort study |
title_fullStr | Risk factors for the COVID‐19 severity and its correlation with viral shedding: A retrospective cohort study |
title_full_unstemmed | Risk factors for the COVID‐19 severity and its correlation with viral shedding: A retrospective cohort study |
title_short | Risk factors for the COVID‐19 severity and its correlation with viral shedding: A retrospective cohort study |
title_sort | risk factors for the covid‐19 severity and its correlation with viral shedding: a retrospective cohort study |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821149/ https://www.ncbi.nlm.nih.gov/pubmed/32725915 http://dx.doi.org/10.1002/jmv.26367 |
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