Cargando…
MS Binding Assays for Glycine Transporter 2 (GlyT2) Employing Org25543 as Reporter Ligand
This study describes the first binding assay for glycine transporter 2 (GlyT2) following the concept of MS Binding Assays. The selective GlyT2 inhibitor Org25543 was employed as a reporter ligand and it was quantified with a highly sensitive and rapid LC‐ESI‐MS/MS method. Binding of Org25543 at GlyT...
Autores principales: | Ackermann, Thomas M., Allmendinger, Lars, Höfner, Georg, Wanner, Klaus T. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821181/ https://www.ncbi.nlm.nih.gov/pubmed/32734692 http://dx.doi.org/10.1002/cmdc.202000342 |
Ejemplares similares
-
Photoswitchable ORG25543 Congener Enables Optical
Control of Glycine Transporter 2
por: Mostyn, Shannon N., et al.
Publicado: (2020) -
Screening for New Inhibitors of Glycine Transporter 1 and 2 by Means of MS Binding Assays
por: Ackermann, Thomas M., et al.
Publicado: (2021) -
Structural Determinants of the Neuronal Glycine Transporter
2 for the Selective Inhibitors ALX1393 and ORG25543
por: Benito-Muñoz, Cristina, et al.
Publicado: (2021) -
Glycinergic transmission: glycine transporter GlyT2 in neuronal pathologies
por: Zafra, Francisco, et al.
Publicado: (2016) -
Calnexin-Assisted Biogenesis of the Neuronal Glycine Transporter 2 (GlyT2)
por: Arribas-González, Esther, et al.
Publicado: (2013)