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Detection challenges in quantitative polymer analysis by liquid chromatography
Accurate quantification of polymer distributions is one of the main challenges in polymer analysis by liquid chromatography. The response of contemporary detectors is typically influenced by compositional features such as molecular weight, chain composition, end groups, and branching. This renders t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821191/ https://www.ncbi.nlm.nih.gov/pubmed/32935906 http://dx.doi.org/10.1002/jssc.202000768 |
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author | Knol, Wouter C. Pirok, Bob W. J. Peters, Ron A. H. |
author_facet | Knol, Wouter C. Pirok, Bob W. J. Peters, Ron A. H. |
author_sort | Knol, Wouter C. |
collection | PubMed |
description | Accurate quantification of polymer distributions is one of the main challenges in polymer analysis by liquid chromatography. The response of contemporary detectors is typically influenced by compositional features such as molecular weight, chain composition, end groups, and branching. This renders the accurate quantification of complex polymers of which there are no standards available, extremely challenging. Moreover, any (programmed) change in mobile‐phase composition may further limit the applicability of detection techniques. Current methods often rely on refractive index detection, which is not accurate when dealing with complex samples as the refractive‐index increment is often unknown. We review current and emerging detection methods in liquid chromatography with the aim of identifying detectors, which can be applied to the quantitative analysis of complex polymers. |
format | Online Article Text |
id | pubmed-7821191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78211912021-01-29 Detection challenges in quantitative polymer analysis by liquid chromatography Knol, Wouter C. Pirok, Bob W. J. Peters, Ron A. H. J Sep Sci Liquid Chromatography Accurate quantification of polymer distributions is one of the main challenges in polymer analysis by liquid chromatography. The response of contemporary detectors is typically influenced by compositional features such as molecular weight, chain composition, end groups, and branching. This renders the accurate quantification of complex polymers of which there are no standards available, extremely challenging. Moreover, any (programmed) change in mobile‐phase composition may further limit the applicability of detection techniques. Current methods often rely on refractive index detection, which is not accurate when dealing with complex samples as the refractive‐index increment is often unknown. We review current and emerging detection methods in liquid chromatography with the aim of identifying detectors, which can be applied to the quantitative analysis of complex polymers. John Wiley and Sons Inc. 2020-10-04 2021-01 /pmc/articles/PMC7821191/ /pubmed/32935906 http://dx.doi.org/10.1002/jssc.202000768 Text en © 2020 The Authors. Journal of Separation Science published by Wiley‐VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Liquid Chromatography Knol, Wouter C. Pirok, Bob W. J. Peters, Ron A. H. Detection challenges in quantitative polymer analysis by liquid chromatography |
title | Detection challenges in quantitative polymer analysis by liquid chromatography |
title_full | Detection challenges in quantitative polymer analysis by liquid chromatography |
title_fullStr | Detection challenges in quantitative polymer analysis by liquid chromatography |
title_full_unstemmed | Detection challenges in quantitative polymer analysis by liquid chromatography |
title_short | Detection challenges in quantitative polymer analysis by liquid chromatography |
title_sort | detection challenges in quantitative polymer analysis by liquid chromatography |
topic | Liquid Chromatography |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821191/ https://www.ncbi.nlm.nih.gov/pubmed/32935906 http://dx.doi.org/10.1002/jssc.202000768 |
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