Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome

Brugada syndrome (BrS) is an inherited arrhythmogenic disease that may lead to sudden cardiac death in young adults with structurally normal hearts. No pharmacological therapy is available for BrS patients. This situation highlights the urgent need to overcome current difficulties by developing nove...

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Detalles Bibliográficos
Autores principales: Di Mauro, Vittoria, Ceriotti, Paola, Lodola, Francesco, Salvarani, Nicolò, Modica, Jessica, Bang, Marie-Louise, Mazzanti, Andrea, Napolitano, Carlo, Priori, Silvia G., Catalucci, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821386/
https://www.ncbi.nlm.nih.gov/pubmed/33488405
http://dx.doi.org/10.3389/fphys.2020.616819

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