Long-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancer

BACKGROUND: Deregulated gene expression is a hallmark of cancer; however, most studies to date have analyzed short-read RNA sequencing data with inherent limitations. Here, we combine PacBio long-read isoform sequencing (Iso-Seq) and Illumina paired-end short-read RNA sequencing to comprehensively s...

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Detalles Bibliográficos
Autores principales: Huang, Kie Kyon, Huang, Jiawen, Wu, Jeanie Kar Leng, Lee, Minghui, Tay, Su Ting, Kumar, Vikrant, Ramnarayanan, Kalpana, Padmanabhan, Nisha, Xu, Chang, Tan, Angie Lay Keng, Chan, Charlene, Kappei, Dennis, Göke, Jonathan, Tan, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821541/
https://www.ncbi.nlm.nih.gov/pubmed/33482911
http://dx.doi.org/10.1186/s13059-021-02261-x

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