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Short‐term meditation training influences brain energy metabolism: A pilot study on (31)P MR spectroscopy
BACKGROUND: Meditation is increasingly attracting interest among neuroimaging researchers for its relevance as a cognitive enhancement technique and several cross‐sectional studies have indicated cerebral changes. This longitudinal study applied a distinct and standardized meditative technique with...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821578/ https://www.ncbi.nlm.nih.gov/pubmed/33300668 http://dx.doi.org/10.1002/brb3.1914 |
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author | Gizewski, Elke R. Steiger, Ruth Waibel, Michaela Pereverzyev, Sergiy Sommer, Patrick J. D. Siedentopf, Christian Grams, Astrid E. Lenhart, Lukas Singewald, Nicolas |
author_facet | Gizewski, Elke R. Steiger, Ruth Waibel, Michaela Pereverzyev, Sergiy Sommer, Patrick J. D. Siedentopf, Christian Grams, Astrid E. Lenhart, Lukas Singewald, Nicolas |
author_sort | Gizewski, Elke R. |
collection | PubMed |
description | BACKGROUND: Meditation is increasingly attracting interest among neuroimaging researchers for its relevance as a cognitive enhancement technique and several cross‐sectional studies have indicated cerebral changes. This longitudinal study applied a distinct and standardized meditative technique with a group of volunteers in a short‐term training program to analyze brain metabolic changes. METHODS: The effect of 7 weeks of meditation exercises (focused attention meditation, FAM) was assessed on 27 healthy volunteers. Changes in cerebral energy metabolism were investigated using (31)P‐MR spectroscopy. Metabolite ratios were compared before (T1) and after training (T2). Additional questionnaire assessments were included. RESULTS: The participants performed FAM daily. Depression and anxiety scores revealed a lower level of state anxiety at T2 compared to T1. From T1 to T2, energy metabolism ratios showed the following differences: PCr/ATP increased right occipitally; Pi/ATP decreased bilaterally in the basal ganglia and temporal lobe on the right; PCr/Pi increased in occipital lobe bilaterally, in the basal ganglia and in the temporal lobe on the right side. The pH decreased temporal on the left side and frontal in the right side. The observed changes in the temporal areas and basal ganglia may be interpreted as a higher energetic state, whereas the frontal and occipital areas showed changes that may be related to a down‐regulation in ATP turnover, energy state, and oxidative capacity. CONCLUSIONS: The results of the current study indicate for the first time in a longitudinal study that even short‐term training in FAM may have considerable effects on brain energy state with different local energy management in specific brain regions. Especially higher energetic state in basal ganglia may represent altered function in their central role in complex cerebral distributed networks including frontal and temporal areas. Further studies including different forms of relaxation techniques should be performed for more specific and reliable insights. |
format | Online Article Text |
id | pubmed-7821578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78215782021-01-29 Short‐term meditation training influences brain energy metabolism: A pilot study on (31)P MR spectroscopy Gizewski, Elke R. Steiger, Ruth Waibel, Michaela Pereverzyev, Sergiy Sommer, Patrick J. D. Siedentopf, Christian Grams, Astrid E. Lenhart, Lukas Singewald, Nicolas Brain Behav Original Research BACKGROUND: Meditation is increasingly attracting interest among neuroimaging researchers for its relevance as a cognitive enhancement technique and several cross‐sectional studies have indicated cerebral changes. This longitudinal study applied a distinct and standardized meditative technique with a group of volunteers in a short‐term training program to analyze brain metabolic changes. METHODS: The effect of 7 weeks of meditation exercises (focused attention meditation, FAM) was assessed on 27 healthy volunteers. Changes in cerebral energy metabolism were investigated using (31)P‐MR spectroscopy. Metabolite ratios were compared before (T1) and after training (T2). Additional questionnaire assessments were included. RESULTS: The participants performed FAM daily. Depression and anxiety scores revealed a lower level of state anxiety at T2 compared to T1. From T1 to T2, energy metabolism ratios showed the following differences: PCr/ATP increased right occipitally; Pi/ATP decreased bilaterally in the basal ganglia and temporal lobe on the right; PCr/Pi increased in occipital lobe bilaterally, in the basal ganglia and in the temporal lobe on the right side. The pH decreased temporal on the left side and frontal in the right side. The observed changes in the temporal areas and basal ganglia may be interpreted as a higher energetic state, whereas the frontal and occipital areas showed changes that may be related to a down‐regulation in ATP turnover, energy state, and oxidative capacity. CONCLUSIONS: The results of the current study indicate for the first time in a longitudinal study that even short‐term training in FAM may have considerable effects on brain energy state with different local energy management in specific brain regions. Especially higher energetic state in basal ganglia may represent altered function in their central role in complex cerebral distributed networks including frontal and temporal areas. Further studies including different forms of relaxation techniques should be performed for more specific and reliable insights. John Wiley and Sons Inc. 2020-12-10 /pmc/articles/PMC7821578/ /pubmed/33300668 http://dx.doi.org/10.1002/brb3.1914 Text en © 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Gizewski, Elke R. Steiger, Ruth Waibel, Michaela Pereverzyev, Sergiy Sommer, Patrick J. D. Siedentopf, Christian Grams, Astrid E. Lenhart, Lukas Singewald, Nicolas Short‐term meditation training influences brain energy metabolism: A pilot study on (31)P MR spectroscopy |
title | Short‐term meditation training influences brain energy metabolism: A pilot study on (31)P MR spectroscopy |
title_full | Short‐term meditation training influences brain energy metabolism: A pilot study on (31)P MR spectroscopy |
title_fullStr | Short‐term meditation training influences brain energy metabolism: A pilot study on (31)P MR spectroscopy |
title_full_unstemmed | Short‐term meditation training influences brain energy metabolism: A pilot study on (31)P MR spectroscopy |
title_short | Short‐term meditation training influences brain energy metabolism: A pilot study on (31)P MR spectroscopy |
title_sort | short‐term meditation training influences brain energy metabolism: a pilot study on (31)p mr spectroscopy |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821578/ https://www.ncbi.nlm.nih.gov/pubmed/33300668 http://dx.doi.org/10.1002/brb3.1914 |
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