Zika virus oncolytic activity requires CD8(+) T cells and is boosted by immune checkpoint blockade

Glioblastoma multiforme (GBM) is a fatal human cancer in part because GBM stem cells are resistant to therapy and recurrence is inevitable. Previously, we demonstrated Zika virus (ZIKV) targets GBM stem cells and prevents death of mice with gliomas. Here, we evaluated the immunological basis of ZIKV...

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Detalles Bibliográficos
Autores principales: Nair, Sharmila, Mazzoccoli, Luciano, Jash, Arijita, Govero, Jennifer, Bais, Sachendra S., Hu, Tong, Fontes-Garfias, Camila R., Shan, Chao, Okada, Hideho, Shresta, Sujan, Rich, Jeremy N., Shi, Pei-Yong, Diamond, Michael S., Chheda, Milan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821591/
https://www.ncbi.nlm.nih.gov/pubmed/33232299
http://dx.doi.org/10.1172/jci.insight.144619

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