Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes

Dedifferentiation has been implicated in β cell dysfunction and loss in rodent diabetes. However, the pathophysiological significance in humans remains unclear. To elucidate this, we analyzed surgically resected pancreatic tissues of 26 Japanese subjects with diabetes and 11 nondiabetic subjects, wh...

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Detalles Bibliográficos
Autores principales: Amo-Shiinoki, Kikuko, Tanabe, Katsuya, Hoshii, Yoshinobu, Matsui, Hiroto, Harano, Risa, Fukuda, Tatsuya, Takeuchi, Takato, Bouchi, Ryotaro, Takagi, Tokiyo, Hatanaka, Masayuki, Takeda, Komei, Okuya, Shigeru, Nishimura, Wataru, Kudo, Atsushi, Tanaka, Shinji, Tanabe, Minoru, Akashi, Takumi, Yamada, Tetsuya, Ogawa, Yoshihiro, Ikeda, Eiji, Nagano, Hiroaki, Tanizawa, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821596/
https://www.ncbi.nlm.nih.gov/pubmed/33427207
http://dx.doi.org/10.1172/jci.insight.143791

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