Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene

Existing animal models of cystic fibrosis (CF) have provided key insights into CF pathogenesis but have been limited by short lifespans, absence of key phenotypes, and/or high maintenance costs. Here, we report the CRISPR/Cas9-mediated generation of CF rabbits, a model with a relatively long lifespa...

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Detalles Bibliográficos
Autores principales: Xu, Jie, Livraghi-Butrico, Alessandra, Hou, Xia, Rajagopalan, Carthic, Zhang, Jifeng, Song, Jun, Jiang, Hong, Wei, Hong-Guang, Wang, Hui, Bouhamdan, Mohamad, Ruan, Jinxue, Yang, Dongshan, Qiu, Yining, Xie, Youming, Barrett, Ronald, McClellan, Sharon, Mou, Hongmei, Wu, Qingtian, Chen, Xuequn, Rogers, Troy D., Wilkinson, Kristen J., Gilmore, Rodney C., Esther, Charles R., Zaman, Khalequz, Liang, Xiubin, Sobolic, Michael, Hazlett, Linda, Zhang, Kezhong, Frizzell, Raymond A., Gentzsch, Martina, O’Neal, Wanda K., Grubb, Barbara R., Chen, Y. Eugene, Boucher, Richard C., Sun, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821608/
https://www.ncbi.nlm.nih.gov/pubmed/33232302
http://dx.doi.org/10.1172/jci.insight.139813

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