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Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease

OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Systemic inflammation and oxidant/antioxidant imbalance has been seen to play a key role in pathogenesis of COPD. The present study investigated the levels of inflammatory and antioxidant...

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Autores principales: Pandey, Sarika, Garg, Rajiv, Kant, Surya, Gaur, Priyanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821825/
https://www.ncbi.nlm.nih.gov/pubmed/33505883
http://dx.doi.org/10.4103/tcmj.tcmj_198_19
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author Pandey, Sarika
Garg, Rajiv
Kant, Surya
Gaur, Priyanka
author_facet Pandey, Sarika
Garg, Rajiv
Kant, Surya
Gaur, Priyanka
author_sort Pandey, Sarika
collection PubMed
description OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Systemic inflammation and oxidant/antioxidant imbalance has been seen to play a key role in pathogenesis of COPD. The present study investigated the levels of inflammatory and antioxidant/oxidative stress biomarker in COPD patients and healthy subjects. MATERIALS AND METHODS: The present study enrolled seventy COPD patients and seventy healthy controls from Department of Respiratory Medicine at a tertiary care hospital. Vitamin D, C-reactive protein (CRP), superoxide dismutase (SOD), catalase, and malondialdehyde (MDA) levels were measured in both cases and control. GraphPad PRISM version 6.01 was used for analysis of data. RESULTS: The levels of Vitamin D, SOD, Catalase, were found to be significantly lower among the COPD patients in comparison to healthy controls while levels of MDA and CRP were significantly higher (P = 0.0001). CONCLUSION: The results showed oxidant/antioxidant imbalance and Vitamin D deficiency in COPD patients. Higher levels of CRP and oxidative stress markers were observed in COPD patients in comparison to healthy controls. A biomarker based study testing the efficacy of novel antioxidant or other agents will be helpful that can modify the course of this disease.
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spelling pubmed-78218252021-01-26 Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease Pandey, Sarika Garg, Rajiv Kant, Surya Gaur, Priyanka Tzu Chi Med J Original Article OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Systemic inflammation and oxidant/antioxidant imbalance has been seen to play a key role in pathogenesis of COPD. The present study investigated the levels of inflammatory and antioxidant/oxidative stress biomarker in COPD patients and healthy subjects. MATERIALS AND METHODS: The present study enrolled seventy COPD patients and seventy healthy controls from Department of Respiratory Medicine at a tertiary care hospital. Vitamin D, C-reactive protein (CRP), superoxide dismutase (SOD), catalase, and malondialdehyde (MDA) levels were measured in both cases and control. GraphPad PRISM version 6.01 was used for analysis of data. RESULTS: The levels of Vitamin D, SOD, Catalase, were found to be significantly lower among the COPD patients in comparison to healthy controls while levels of MDA and CRP were significantly higher (P = 0.0001). CONCLUSION: The results showed oxidant/antioxidant imbalance and Vitamin D deficiency in COPD patients. Higher levels of CRP and oxidative stress markers were observed in COPD patients in comparison to healthy controls. A biomarker based study testing the efficacy of novel antioxidant or other agents will be helpful that can modify the course of this disease. Wolters Kluwer - Medknow 2019-12-05 /pmc/articles/PMC7821825/ /pubmed/33505883 http://dx.doi.org/10.4103/tcmj.tcmj_198_19 Text en Copyright: © 2019 Tzu Chi Medical Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Pandey, Sarika
Garg, Rajiv
Kant, Surya
Gaur, Priyanka
Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease
title Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease
title_full Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease
title_fullStr Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease
title_full_unstemmed Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease
title_short Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease
title_sort vitamin d, c-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821825/
https://www.ncbi.nlm.nih.gov/pubmed/33505883
http://dx.doi.org/10.4103/tcmj.tcmj_198_19
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