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Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease
OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Systemic inflammation and oxidant/antioxidant imbalance has been seen to play a key role in pathogenesis of COPD. The present study investigated the levels of inflammatory and antioxidant...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821825/ https://www.ncbi.nlm.nih.gov/pubmed/33505883 http://dx.doi.org/10.4103/tcmj.tcmj_198_19 |
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author | Pandey, Sarika Garg, Rajiv Kant, Surya Gaur, Priyanka |
author_facet | Pandey, Sarika Garg, Rajiv Kant, Surya Gaur, Priyanka |
author_sort | Pandey, Sarika |
collection | PubMed |
description | OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Systemic inflammation and oxidant/antioxidant imbalance has been seen to play a key role in pathogenesis of COPD. The present study investigated the levels of inflammatory and antioxidant/oxidative stress biomarker in COPD patients and healthy subjects. MATERIALS AND METHODS: The present study enrolled seventy COPD patients and seventy healthy controls from Department of Respiratory Medicine at a tertiary care hospital. Vitamin D, C-reactive protein (CRP), superoxide dismutase (SOD), catalase, and malondialdehyde (MDA) levels were measured in both cases and control. GraphPad PRISM version 6.01 was used for analysis of data. RESULTS: The levels of Vitamin D, SOD, Catalase, were found to be significantly lower among the COPD patients in comparison to healthy controls while levels of MDA and CRP were significantly higher (P = 0.0001). CONCLUSION: The results showed oxidant/antioxidant imbalance and Vitamin D deficiency in COPD patients. Higher levels of CRP and oxidative stress markers were observed in COPD patients in comparison to healthy controls. A biomarker based study testing the efficacy of novel antioxidant or other agents will be helpful that can modify the course of this disease. |
format | Online Article Text |
id | pubmed-7821825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-78218252021-01-26 Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease Pandey, Sarika Garg, Rajiv Kant, Surya Gaur, Priyanka Tzu Chi Med J Original Article OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Systemic inflammation and oxidant/antioxidant imbalance has been seen to play a key role in pathogenesis of COPD. The present study investigated the levels of inflammatory and antioxidant/oxidative stress biomarker in COPD patients and healthy subjects. MATERIALS AND METHODS: The present study enrolled seventy COPD patients and seventy healthy controls from Department of Respiratory Medicine at a tertiary care hospital. Vitamin D, C-reactive protein (CRP), superoxide dismutase (SOD), catalase, and malondialdehyde (MDA) levels were measured in both cases and control. GraphPad PRISM version 6.01 was used for analysis of data. RESULTS: The levels of Vitamin D, SOD, Catalase, were found to be significantly lower among the COPD patients in comparison to healthy controls while levels of MDA and CRP were significantly higher (P = 0.0001). CONCLUSION: The results showed oxidant/antioxidant imbalance and Vitamin D deficiency in COPD patients. Higher levels of CRP and oxidative stress markers were observed in COPD patients in comparison to healthy controls. A biomarker based study testing the efficacy of novel antioxidant or other agents will be helpful that can modify the course of this disease. Wolters Kluwer - Medknow 2019-12-05 /pmc/articles/PMC7821825/ /pubmed/33505883 http://dx.doi.org/10.4103/tcmj.tcmj_198_19 Text en Copyright: © 2019 Tzu Chi Medical Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Pandey, Sarika Garg, Rajiv Kant, Surya Gaur, Priyanka Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease |
title | Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease |
title_full | Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease |
title_fullStr | Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease |
title_full_unstemmed | Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease |
title_short | Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease |
title_sort | vitamin d, c-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821825/ https://www.ncbi.nlm.nih.gov/pubmed/33505883 http://dx.doi.org/10.4103/tcmj.tcmj_198_19 |
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