Cargando…
Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients
Although somatic mutations in Histone 3.3 (H3.3) are well-studied drivers of oncogenesis, the role of germline mutations remains unreported. We analyze 46 patients bearing de novo germline mutations in histone 3 family 3A (H3F3A) or H3F3B with progressive neurologic dysfunction and congenital anomal...
Ejemplares similares
-
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant
por: Earnshaw, W. C., et al.
Publicado: (2013) -
Histone H3 phosphorylation near the nucleosome dyad alters chromatin structure
por: North, Justin A., et al.
Publicado: (2014) -
Phosphorylation of histone H3(T118) alters nucleosome dynamics and remodeling
por: North, Justin A., et al.
Publicado: (2011) -
Recapitulation of Tumor Heterogeneity and Molecular Signatures in a 3D Brain Cancer Model with Decreased Sensitivity to Histone Deacetylase Inhibition
por: Smith, Stuart J., et al.
Publicado: (2012) -
Sex affects immunolabeling for histone 3 K27me3 in the trophectoderm of the bovine blastocyst but not labeling for histone 3 K18ac
por: Carvalheira, Luciano de R., et al.
Publicado: (2019)