Standalone or combinatorial phenylbutyrate therapy shows excellent antiviral activity and mimics CREB3 silencing

Herpesviruses are ubiquitous human pathogens that tightly regulate many cellular pathways including the unfolded protein response to endoplasmic reticulum (ER) stress. Pharmacological modulation of this pathway results in the inhibition of viral replication. In this study, we tested 4-phenylbutyrate...

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Detalles Bibliográficos
Autores principales: Yadavalli, Tejabhiram, Suryawanshi, Rahul, Koganti, Raghuram, Hopkins, James, Ames, Joshua, Koujah, Lulia, Iqbal, Aqsa, Madavaraju, Krishnaraju, Agelidis, Alex, Shukla, Deepak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821892/
https://www.ncbi.nlm.nih.gov/pubmed/33277262
http://dx.doi.org/10.1126/sciadv.abd9443

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