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Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil

Congenital viral infections and the occurrence of septo-optic dysplasia, which is a combination of optic nerve hypoplasia, abnormal formation of structures along the midline of the brain, and pituitary hypofunction, support the biological plausibility of endocrine dysfunction in Zika-related microce...

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Autores principales: Veras Gonçalves, Andréia, Miranda-Filho, Demócrito de B., Rocha Vilela, Líbia Cristina, Ramos, Regina Coeli Ferreira, de Araújo, Thalia V. B., de Vasconcelos, Rômulo A. L., Wanderley Rocha, Maria Angela, Eickmann, Sophie Helena, Cordeiro, Marli Tenório, Ventura, Liana O., Montarroyos, Ulisses Ramos, Mertens Brainer, Alessandra, Costa Gomes, Maria Durce, da Silva, Paula Fabiana Sobral, Martelli, Celina M. T., Brickley, Elizabeth B., Ximenes, Ricardo A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821916/
https://www.ncbi.nlm.nih.gov/pubmed/33374895
http://dx.doi.org/10.3390/v13010001
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author Veras Gonçalves, Andréia
Miranda-Filho, Demócrito de B.
Rocha Vilela, Líbia Cristina
Ramos, Regina Coeli Ferreira
de Araújo, Thalia V. B.
de Vasconcelos, Rômulo A. L.
Wanderley Rocha, Maria Angela
Eickmann, Sophie Helena
Cordeiro, Marli Tenório
Ventura, Liana O.
Montarroyos, Ulisses Ramos
Mertens Brainer, Alessandra
Costa Gomes, Maria Durce
da Silva, Paula Fabiana Sobral
Martelli, Celina M. T.
Brickley, Elizabeth B.
Ximenes, Ricardo A. A.
author_facet Veras Gonçalves, Andréia
Miranda-Filho, Demócrito de B.
Rocha Vilela, Líbia Cristina
Ramos, Regina Coeli Ferreira
de Araújo, Thalia V. B.
de Vasconcelos, Rômulo A. L.
Wanderley Rocha, Maria Angela
Eickmann, Sophie Helena
Cordeiro, Marli Tenório
Ventura, Liana O.
Montarroyos, Ulisses Ramos
Mertens Brainer, Alessandra
Costa Gomes, Maria Durce
da Silva, Paula Fabiana Sobral
Martelli, Celina M. T.
Brickley, Elizabeth B.
Ximenes, Ricardo A. A.
author_sort Veras Gonçalves, Andréia
collection PubMed
description Congenital viral infections and the occurrence of septo-optic dysplasia, which is a combination of optic nerve hypoplasia, abnormal formation of structures along the midline of the brain, and pituitary hypofunction, support the biological plausibility of endocrine dysfunction in Zika-related microcephaly. In this case series we ascertained the presence and describe endocrine dysfunction in 30 children with severe Zika-related microcephaly from the MERG Pediatric Cohort, referred for endocrinological evaluation between February and August 2019. Of the 30 children, 97% had severe microcephaly. The average age at the endocrinological consultation was 41 months and 53% were female. The most frequently observed endocrine dysfunctions comprised short stature, hypothyroidism, obesity and variants early puberty. These dysfunctions occurred alone 57% or in combination 43%. We found optic nerve hypoplasia (6/21) and corpus callosum hypoplasia (20/21). Seizure crises were reported in 86% of the children. The most common—and clinically important—endocrine dysfunctions were pubertal dysfunctions, thyroid disease, growth impairment, and obesity. These dysfunctions require careful monitoring and signal the need for endocrinological evaluation in children with Zika-related microcephaly, in order to make early diagnoses and implement appropriate treatment when necessary.
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spelling pubmed-78219162021-01-23 Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil Veras Gonçalves, Andréia Miranda-Filho, Demócrito de B. Rocha Vilela, Líbia Cristina Ramos, Regina Coeli Ferreira de Araújo, Thalia V. B. de Vasconcelos, Rômulo A. L. Wanderley Rocha, Maria Angela Eickmann, Sophie Helena Cordeiro, Marli Tenório Ventura, Liana O. Montarroyos, Ulisses Ramos Mertens Brainer, Alessandra Costa Gomes, Maria Durce da Silva, Paula Fabiana Sobral Martelli, Celina M. T. Brickley, Elizabeth B. Ximenes, Ricardo A. A. Viruses Article Congenital viral infections and the occurrence of septo-optic dysplasia, which is a combination of optic nerve hypoplasia, abnormal formation of structures along the midline of the brain, and pituitary hypofunction, support the biological plausibility of endocrine dysfunction in Zika-related microcephaly. In this case series we ascertained the presence and describe endocrine dysfunction in 30 children with severe Zika-related microcephaly from the MERG Pediatric Cohort, referred for endocrinological evaluation between February and August 2019. Of the 30 children, 97% had severe microcephaly. The average age at the endocrinological consultation was 41 months and 53% were female. The most frequently observed endocrine dysfunctions comprised short stature, hypothyroidism, obesity and variants early puberty. These dysfunctions occurred alone 57% or in combination 43%. We found optic nerve hypoplasia (6/21) and corpus callosum hypoplasia (20/21). Seizure crises were reported in 86% of the children. The most common—and clinically important—endocrine dysfunctions were pubertal dysfunctions, thyroid disease, growth impairment, and obesity. These dysfunctions require careful monitoring and signal the need for endocrinological evaluation in children with Zika-related microcephaly, in order to make early diagnoses and implement appropriate treatment when necessary. MDPI 2020-12-22 /pmc/articles/PMC7821916/ /pubmed/33374895 http://dx.doi.org/10.3390/v13010001 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Veras Gonçalves, Andréia
Miranda-Filho, Demócrito de B.
Rocha Vilela, Líbia Cristina
Ramos, Regina Coeli Ferreira
de Araújo, Thalia V. B.
de Vasconcelos, Rômulo A. L.
Wanderley Rocha, Maria Angela
Eickmann, Sophie Helena
Cordeiro, Marli Tenório
Ventura, Liana O.
Montarroyos, Ulisses Ramos
Mertens Brainer, Alessandra
Costa Gomes, Maria Durce
da Silva, Paula Fabiana Sobral
Martelli, Celina M. T.
Brickley, Elizabeth B.
Ximenes, Ricardo A. A.
Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil
title Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil
title_full Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil
title_fullStr Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil
title_full_unstemmed Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil
title_short Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil
title_sort endocrine dysfunction in children with zika-related microcephaly who were born during the 2015 epidemic in the state of pernambuco, brazil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821916/
https://www.ncbi.nlm.nih.gov/pubmed/33374895
http://dx.doi.org/10.3390/v13010001
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