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A comparative study of human betacoronavirus spike proteins: structure, function and therapeutics
Coronaviruses are the paradigm of emerging 21(st) century zoonotic viruses, triggering numerous outbreaks and a severe global health crisis. The current COVID-19 pandemic caused by SARS-CoV-2 has affected more than 51 million people across the globe as of 12 November 2020. The crown-like spikes on t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821988/ https://www.ncbi.nlm.nih.gov/pubmed/33483791 http://dx.doi.org/10.1007/s00705-021-04961-y |
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author | Verma, Jyoti Subbarao, Naidu |
author_facet | Verma, Jyoti Subbarao, Naidu |
author_sort | Verma, Jyoti |
collection | PubMed |
description | Coronaviruses are the paradigm of emerging 21(st) century zoonotic viruses, triggering numerous outbreaks and a severe global health crisis. The current COVID-19 pandemic caused by SARS-CoV-2 has affected more than 51 million people across the globe as of 12 November 2020. The crown-like spikes on the surface of the virion are the unique structural feature of viruses in the family Coronaviridae. The spike (S) protein adopts distinct conformations while mediating entry of the virus into the host. This multifunctional protein mediates the entry process by recognizing its receptor on the host cell, followed by the fusion of the viral membrane with the host cell membrane. This review article focuses on the structural and functional comparison of S proteins of the human betacoronaviruses, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we review the current state of knowledge about receptor recognition, the membrane fusion mechanism, structural epitopes, and glycosylation sites of the S proteins of these viruses. We further discuss various vaccines and other therapeutics such as monoclonal antibodies, peptides, and small molecules based on the S protein of these three viruses. |
format | Online Article Text |
id | pubmed-7821988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-78219882021-01-25 A comparative study of human betacoronavirus spike proteins: structure, function and therapeutics Verma, Jyoti Subbarao, Naidu Arch Virol Review Coronaviruses are the paradigm of emerging 21(st) century zoonotic viruses, triggering numerous outbreaks and a severe global health crisis. The current COVID-19 pandemic caused by SARS-CoV-2 has affected more than 51 million people across the globe as of 12 November 2020. The crown-like spikes on the surface of the virion are the unique structural feature of viruses in the family Coronaviridae. The spike (S) protein adopts distinct conformations while mediating entry of the virus into the host. This multifunctional protein mediates the entry process by recognizing its receptor on the host cell, followed by the fusion of the viral membrane with the host cell membrane. This review article focuses on the structural and functional comparison of S proteins of the human betacoronaviruses, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we review the current state of knowledge about receptor recognition, the membrane fusion mechanism, structural epitopes, and glycosylation sites of the S proteins of these viruses. We further discuss various vaccines and other therapeutics such as monoclonal antibodies, peptides, and small molecules based on the S protein of these three viruses. Springer Vienna 2021-01-22 2021 /pmc/articles/PMC7821988/ /pubmed/33483791 http://dx.doi.org/10.1007/s00705-021-04961-y Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH, AT part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Verma, Jyoti Subbarao, Naidu A comparative study of human betacoronavirus spike proteins: structure, function and therapeutics |
title | A comparative study of human betacoronavirus spike proteins: structure, function and therapeutics |
title_full | A comparative study of human betacoronavirus spike proteins: structure, function and therapeutics |
title_fullStr | A comparative study of human betacoronavirus spike proteins: structure, function and therapeutics |
title_full_unstemmed | A comparative study of human betacoronavirus spike proteins: structure, function and therapeutics |
title_short | A comparative study of human betacoronavirus spike proteins: structure, function and therapeutics |
title_sort | comparative study of human betacoronavirus spike proteins: structure, function and therapeutics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821988/ https://www.ncbi.nlm.nih.gov/pubmed/33483791 http://dx.doi.org/10.1007/s00705-021-04961-y |
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