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Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study

Oral pathogens have been identified in bioptic specimens from Age-Related Macular Degeneration (ARMD) patients, and alveolar bone loss has been related to ARMD. Therefore, the possible association between ARMD and periodontal disease was investigated in the present case-control study, evaluating cli...

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Autores principales: Di Spirito, Federica, La Rocca, Michele, De Bernardo, Maddalena, Rosa, Nicola, Sbordone, Carolina, Sbordone, Ludovico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822008/
https://www.ncbi.nlm.nih.gov/pubmed/33374995
http://dx.doi.org/10.3390/dj9010001
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author Di Spirito, Federica
La Rocca, Michele
De Bernardo, Maddalena
Rosa, Nicola
Sbordone, Carolina
Sbordone, Ludovico
author_facet Di Spirito, Federica
La Rocca, Michele
De Bernardo, Maddalena
Rosa, Nicola
Sbordone, Carolina
Sbordone, Ludovico
author_sort Di Spirito, Federica
collection PubMed
description Oral pathogens have been identified in bioptic specimens from Age-Related Macular Degeneration (ARMD) patients, and alveolar bone loss has been related to ARMD. Therefore, the possible association between ARMD and periodontal disease was investigated in the present case-control study, evaluating clinical and radiographic periodontal parameters, primarily, in cases vs. controls and, secondarily, in relation to ARMD risk factors, in cases, to highlight a possible pathogenic link between the disorders. Forty ARMD cases and 40 non-ARMD controls, matched for age (±3 years) and gender and homogeneous for ARMD risk factors, therefore comparable, underwent full-mouth periodontal charting, panoramic radiograph, and medical data, including ARMD risk factors, collection. Statistical analysis was conducted using the language R. Comparisons between groups were made using both traditional t-tests and Yuen’s test with bootstrap calibration. Enrolled subjects were ≥55 years old, and 50 females and 30 males were equally distributed among the two groups. No statistically significant difference was found in clinical and radiographic periodontal parameters in cases vs. controls. In the case group, no differences were found when relating the periodontal parameters to ARMD risk factors, except for Clinical Attachment Level values that were statistically significantly higher in hypertensive ARMD subjects. A possible association between periodontal disease and ARMD may be hypothesized in hypertensive ARMD subjects, with hypertension as a possible pathogenic link between the disorders.
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spelling pubmed-78220082021-01-23 Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study Di Spirito, Federica La Rocca, Michele De Bernardo, Maddalena Rosa, Nicola Sbordone, Carolina Sbordone, Ludovico Dent J (Basel) Article Oral pathogens have been identified in bioptic specimens from Age-Related Macular Degeneration (ARMD) patients, and alveolar bone loss has been related to ARMD. Therefore, the possible association between ARMD and periodontal disease was investigated in the present case-control study, evaluating clinical and radiographic periodontal parameters, primarily, in cases vs. controls and, secondarily, in relation to ARMD risk factors, in cases, to highlight a possible pathogenic link between the disorders. Forty ARMD cases and 40 non-ARMD controls, matched for age (±3 years) and gender and homogeneous for ARMD risk factors, therefore comparable, underwent full-mouth periodontal charting, panoramic radiograph, and medical data, including ARMD risk factors, collection. Statistical analysis was conducted using the language R. Comparisons between groups were made using both traditional t-tests and Yuen’s test with bootstrap calibration. Enrolled subjects were ≥55 years old, and 50 females and 30 males were equally distributed among the two groups. No statistically significant difference was found in clinical and radiographic periodontal parameters in cases vs. controls. In the case group, no differences were found when relating the periodontal parameters to ARMD risk factors, except for Clinical Attachment Level values that were statistically significantly higher in hypertensive ARMD subjects. A possible association between periodontal disease and ARMD may be hypothesized in hypertensive ARMD subjects, with hypertension as a possible pathogenic link between the disorders. MDPI 2020-12-22 /pmc/articles/PMC7822008/ /pubmed/33374995 http://dx.doi.org/10.3390/dj9010001 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Di Spirito, Federica
La Rocca, Michele
De Bernardo, Maddalena
Rosa, Nicola
Sbordone, Carolina
Sbordone, Ludovico
Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study
title Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study
title_full Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study
title_fullStr Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study
title_full_unstemmed Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study
title_short Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study
title_sort possible association of periodontal disease and macular degeneration: a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822008/
https://www.ncbi.nlm.nih.gov/pubmed/33374995
http://dx.doi.org/10.3390/dj9010001
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