Cargando…

4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells

Age-related macular degeneration (AMD) is a progressive eye disease that causes irreversible impairment of central vision, and effective treatment is not yet available. Extracellular accumulation of amyloid-beta (Aβ) in drusen that lie under the retinal pigment epithelium (RPE) has been reported as...

Descripción completa

Detalles Bibliográficos
Autores principales: Varinthra, Peeraporn, Huang, Shun-Ping, Chompoopong, Supin, Wen, Zhi-Hong, Liu, Ingrid Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822165/
https://www.ncbi.nlm.nih.gov/pubmed/33374505
http://dx.doi.org/10.3390/md19010001
_version_ 1783639569928814592
author Varinthra, Peeraporn
Huang, Shun-Ping
Chompoopong, Supin
Wen, Zhi-Hong
Liu, Ingrid Y.
author_facet Varinthra, Peeraporn
Huang, Shun-Ping
Chompoopong, Supin
Wen, Zhi-Hong
Liu, Ingrid Y.
author_sort Varinthra, Peeraporn
collection PubMed
description Age-related macular degeneration (AMD) is a progressive eye disease that causes irreversible impairment of central vision, and effective treatment is not yet available. Extracellular accumulation of amyloid-beta (Aβ) in drusen that lie under the retinal pigment epithelium (RPE) has been reported as one of the early signs of AMD and was found in more than 60% of Alzheimer’s disease (AD) patients. Extracellular deposition of Aβ can induce the expression of inflammatory cytokines such as IL-1β, TNF-α, COX-2, and iNOS in RPE cells. Thus, finding a compound that can effectively reduce the inflammatory response may help the treatment of AMD. In this research, we investigated the anti-inflammatory effect of the coral-derived compound 4-(phenylsulfanyl) butan-2-one (4-PSB-2) on Aβ(1-42) oligomer (oAβ(1-42)) added to the human adult retinal pigment epithelial cell line (ARPE-19). Our results demonstrated that 4-PSB-2 can decrease the elevated expressions of TNF-α, COX-2, and iNOS via NF-κB signaling in ARPE-19 cells treated with oAβ(1-42) without causing any cytotoxicity or notable side effects. This study suggests that 4-PSB-2 is a promising drug candidate for attenuation of AMD.
format Online
Article
Text
id pubmed-7822165
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-78221652021-01-23 4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells Varinthra, Peeraporn Huang, Shun-Ping Chompoopong, Supin Wen, Zhi-Hong Liu, Ingrid Y. Mar Drugs Article Age-related macular degeneration (AMD) is a progressive eye disease that causes irreversible impairment of central vision, and effective treatment is not yet available. Extracellular accumulation of amyloid-beta (Aβ) in drusen that lie under the retinal pigment epithelium (RPE) has been reported as one of the early signs of AMD and was found in more than 60% of Alzheimer’s disease (AD) patients. Extracellular deposition of Aβ can induce the expression of inflammatory cytokines such as IL-1β, TNF-α, COX-2, and iNOS in RPE cells. Thus, finding a compound that can effectively reduce the inflammatory response may help the treatment of AMD. In this research, we investigated the anti-inflammatory effect of the coral-derived compound 4-(phenylsulfanyl) butan-2-one (4-PSB-2) on Aβ(1-42) oligomer (oAβ(1-42)) added to the human adult retinal pigment epithelial cell line (ARPE-19). Our results demonstrated that 4-PSB-2 can decrease the elevated expressions of TNF-α, COX-2, and iNOS via NF-κB signaling in ARPE-19 cells treated with oAβ(1-42) without causing any cytotoxicity or notable side effects. This study suggests that 4-PSB-2 is a promising drug candidate for attenuation of AMD. MDPI 2020-12-23 /pmc/articles/PMC7822165/ /pubmed/33374505 http://dx.doi.org/10.3390/md19010001 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Varinthra, Peeraporn
Huang, Shun-Ping
Chompoopong, Supin
Wen, Zhi-Hong
Liu, Ingrid Y.
4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells
title 4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells
title_full 4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells
title_fullStr 4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells
title_full_unstemmed 4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells
title_short 4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells
title_sort 4-(phenylsulfanyl) butan-2-one attenuates the inflammatory response induced by amyloid-β oligomers in retinal pigment epithelium cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822165/
https://www.ncbi.nlm.nih.gov/pubmed/33374505
http://dx.doi.org/10.3390/md19010001
work_keys_str_mv AT varinthrapeeraporn 4phenylsulfanylbutan2oneattenuatestheinflammatoryresponseinducedbyamyloidboligomersinretinalpigmentepitheliumcells
AT huangshunping 4phenylsulfanylbutan2oneattenuatestheinflammatoryresponseinducedbyamyloidboligomersinretinalpigmentepitheliumcells
AT chompoopongsupin 4phenylsulfanylbutan2oneattenuatestheinflammatoryresponseinducedbyamyloidboligomersinretinalpigmentepitheliumcells
AT wenzhihong 4phenylsulfanylbutan2oneattenuatestheinflammatoryresponseinducedbyamyloidboligomersinretinalpigmentepitheliumcells
AT liuingridy 4phenylsulfanylbutan2oneattenuatestheinflammatoryresponseinducedbyamyloidboligomersinretinalpigmentepitheliumcells