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A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract (Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk

(1) Background: Due to its richness in chlorogenic acids (CGAs), Maté (Ilex paraguariensis A. St.-Hil.) could be of interest in the prevention of cardiometabolic diseases, however clinical evidence are lacking. This trial aimed to evaluate the impact of maté CGAs, consumed in a daily dose achievable...

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Autores principales: Gebara, Karimi S., Gasparotto Junior, Arquimedes, Palozi, Rhanany A. C., Morand, Christine, Bonetti, Carla I., Gozzi, Paula T., de Mello, Martha R. F., Costa, Telma A., Cardozo Junior, Euclides L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822211/
https://www.ncbi.nlm.nih.gov/pubmed/33374524
http://dx.doi.org/10.3390/nu13010014
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author Gebara, Karimi S.
Gasparotto Junior, Arquimedes
Palozi, Rhanany A. C.
Morand, Christine
Bonetti, Carla I.
Gozzi, Paula T.
de Mello, Martha R. F.
Costa, Telma A.
Cardozo Junior, Euclides L.
author_facet Gebara, Karimi S.
Gasparotto Junior, Arquimedes
Palozi, Rhanany A. C.
Morand, Christine
Bonetti, Carla I.
Gozzi, Paula T.
de Mello, Martha R. F.
Costa, Telma A.
Cardozo Junior, Euclides L.
author_sort Gebara, Karimi S.
collection PubMed
description (1) Background: Due to its richness in chlorogenic acids (CGAs), Maté (Ilex paraguariensis A. St.-Hil.) could be of interest in the prevention of cardiometabolic diseases, however clinical evidence are lacking. This trial aimed to evaluate the impact of maté CGAs, consumed in a daily dose achievable through traditional maté beverages, on parameters related to cardiometabolic risk. (2) Design: Thirty-four male volunteers aged 45–65 years and with at most one criteria of metabolic syndrome, were recruited for a randomized, double-blind, placebo-controlled, and crossover study. The volunteers were assigned to consume an encapsulated dry maté extract for four-weeks, providing 580 mg of caffeoyl quinic acid derivatives (CQAs) daily, or a placebo, with a two weeks washout between intervention periods. Anthropometric variables, blood pressure, plasma glucose, lipids, endothelial, and inflammatory biomarkers were measured in overnight-fasted subjects and after a glucose load. (3) Results: We found no significant effects of treatment on these parameters and the response to the glucose load was also similar between the two interventions. However, a significant decrease in fasting glucose was observed between day 0 and day 28 for the maté group only (−0.57 ± 0.11 mmol/L, p < 0.0002). In subjects with an intermediate to high Framingham risk score, consumption of maté extract induced a 10% increase of high-density lipoprotein (HDL)-c from baseline. In a subgroup representative of the study population, significant decreases in the C-reactive protein (CRP) (−50%) and interleukin-6 (IL-6) (−19%) levels were observed. (4) Conclusions: These clinical observations suggest that maté, naturally rich in CGAs, could improve some cardiometabolic markers in subjects with a higher predisposition to metabolic syndrome, even if that remains to be confirmed in new trials specifically targeting this population.
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spelling pubmed-78222112021-01-23 A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract (Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk Gebara, Karimi S. Gasparotto Junior, Arquimedes Palozi, Rhanany A. C. Morand, Christine Bonetti, Carla I. Gozzi, Paula T. de Mello, Martha R. F. Costa, Telma A. Cardozo Junior, Euclides L. Nutrients Article (1) Background: Due to its richness in chlorogenic acids (CGAs), Maté (Ilex paraguariensis A. St.-Hil.) could be of interest in the prevention of cardiometabolic diseases, however clinical evidence are lacking. This trial aimed to evaluate the impact of maté CGAs, consumed in a daily dose achievable through traditional maté beverages, on parameters related to cardiometabolic risk. (2) Design: Thirty-four male volunteers aged 45–65 years and with at most one criteria of metabolic syndrome, were recruited for a randomized, double-blind, placebo-controlled, and crossover study. The volunteers were assigned to consume an encapsulated dry maté extract for four-weeks, providing 580 mg of caffeoyl quinic acid derivatives (CQAs) daily, or a placebo, with a two weeks washout between intervention periods. Anthropometric variables, blood pressure, plasma glucose, lipids, endothelial, and inflammatory biomarkers were measured in overnight-fasted subjects and after a glucose load. (3) Results: We found no significant effects of treatment on these parameters and the response to the glucose load was also similar between the two interventions. However, a significant decrease in fasting glucose was observed between day 0 and day 28 for the maté group only (−0.57 ± 0.11 mmol/L, p < 0.0002). In subjects with an intermediate to high Framingham risk score, consumption of maté extract induced a 10% increase of high-density lipoprotein (HDL)-c from baseline. In a subgroup representative of the study population, significant decreases in the C-reactive protein (CRP) (−50%) and interleukin-6 (IL-6) (−19%) levels were observed. (4) Conclusions: These clinical observations suggest that maté, naturally rich in CGAs, could improve some cardiometabolic markers in subjects with a higher predisposition to metabolic syndrome, even if that remains to be confirmed in new trials specifically targeting this population. MDPI 2020-12-23 /pmc/articles/PMC7822211/ /pubmed/33374524 http://dx.doi.org/10.3390/nu13010014 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gebara, Karimi S.
Gasparotto Junior, Arquimedes
Palozi, Rhanany A. C.
Morand, Christine
Bonetti, Carla I.
Gozzi, Paula T.
de Mello, Martha R. F.
Costa, Telma A.
Cardozo Junior, Euclides L.
A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract (Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk
title A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract (Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk
title_full A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract (Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk
title_fullStr A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract (Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk
title_full_unstemmed A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract (Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk
title_short A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract (Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk
title_sort randomized crossover intervention study on the effect a standardized maté extract (ilex paraguariensis a. st.-hil.) in men predisposed to cardiovascular risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822211/
https://www.ncbi.nlm.nih.gov/pubmed/33374524
http://dx.doi.org/10.3390/nu13010014
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