Cargando…

Empagliflozin Regulates the AdipoR1/p-AMPK/p-ACC Pathway to Alleviate Lipid Deposition in Diabetic Nephropathy

BACKGROUND: Abnormal lipid deposition in the progress of diabetic nephropathy (DN) plays an important role in a number of studies that have shown that SGLT2 inhibitor (SGLT2i) empagliflozin plays an important role in lipid metabolism, but its mechanism is still unclear. METHODS: We aimed to explore...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Zhiqin, Ni, Lihua, Zhang, Lian, Zha, Dongqing, Hu, Chun, Zhang, Lingli, Feng, Huiling, Wei, Xiaobao, Wu, Xiaoyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822229/ https://www.ncbi.nlm.nih.gov/pubmed/33500643 http://dx.doi.org/10.2147/DMSO.S289712

Ejemplares similares

Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy
por: Park, Hoon Suk, et al.
Publicado: (2016)

Erratum to: Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy
por: Park, Hoon Suk, et al.
Publicado: (2016)

AdipoRon Engages Microglia to Antinociception through the AdipoR1/AMPK Pathway in SNI Mice
por: Fang, Qian, et al.
Publicado: (2023)

AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice
por: Iwabu, Masato, et al.
Publicado: (2021)

Expression of AdipoR1 and AdipoR2 Receptors as Leptin-Breast Cancer Regulation Mechanisms
por: Mociño-Rodríguez, Martha Daniela, et al.
Publicado: (2017)

Age Associated Changes in Transcription of Adiponectin, AdipoR1 and AdipoR2 Genes in Pancreas of Rats
por: Feyzi, Marziyeh, et al.
Publicado: (2020)

Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects
por: Keshvari, Sahar, et al.
Publicado: (2017)

AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin
por: Ruiz, Mario, et al.
Publicado: (2019)

AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway
por: Jie, Chen, et al.
Publicado: (2021)

Expression of adiponectin receptors 1 (AdipoR1) and 2 (AdipoR2) in the porcine pituitary during the oestrous cycle
por: Kiezun, Marta, et al.
Publicado: (2013)

Adiponectin Protects Against Cerebral Ischemic Injury Through AdipoR1/AMPK Pathways
por: Liu, Bin, et al.
Publicado: (2019)

AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice
por: Zatorski, Hubert, et al.
Publicado: (2021)

Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2
por: Tanabe, Hiroaki, et al.
Publicado: (2015)

Striking membrane defects in AdipoR-deficient cells
por: Ruiz, Mario, et al.
Publicado: (2023)

AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis
por: Xu, Hongjiao, et al.
Publicado: (2020)

in vitro Anti-Proliferative Effect of Adiponectin on Human Endometriotic Stromal Cells through AdipoR1 and AdipoR2 Gene Receptor Expression
por: Bohlouli, Somayeh, et al.
Publicado: (2016)

Associations of adiponectin receptor 2 (AdipoR2) gene polymorphisms and AdipoR2 protein expression levels with the risk of colorectal cancer: A case-control study
por: Zhou, Lei, et al.
Publicado: (2017)

Author Correction: AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis
por: Xu, Hongjiao, et al.
Publicado: (2021)

Adiponectin/AdipoR Research and Its Implications for Lifestyle-Related Diseases
por: Iwabu, Masato, et al.
Publicado: (2019)

Molecular cloning and expression analysis of adiponectin and its receptors (AdipoR1 and AdipoR2) in the hypothalamus of the Huoyan goose during different stages of the egg-laying cycle
por: Cao, Zhongzan, et al.
Publicado: (2015)

APN Expression in Serum and Corpus Luteum: Regulation of Luteal Steroidogenesis Is Possibly Dependent on the AdipoR2/AMPK Pathway in Goats
por: Pei, Xiaomeng, et al.
Publicado: (2023)

Human adiponectin receptor AdipoR1 assumes closed and open structures
por: Tanabe, Hiroaki, et al.
Publicado: (2020)

miR-6835-3p regulates the function of pancreatic islet cells by modulating the expression of AdipoR1
por: Wang, Huimin, et al.
Publicado: (2018)

LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1
por: Sun, Lin-Yu, et al.
Publicado: (2018)

Adiponectin inhibits cardiac arrest/cardiopulmonary resuscitation-induced apoptosis in brain by increasing autophagy involved in AdipoR1-AMPK signaling
por: He, Yarong, et al.
Publicado: (2020)

Neuroprotective effects of osmotin in Parkinson’s disease-associated pathology via the AdipoR1/MAPK/AMPK/mTOR signaling pathways
por: Park, Jun Sung, et al.
Publicado: (2023)

Lonicerae Japonicae Flos extract and chlorogenic acid attenuates high-fat-diet- induced prediabetes via CTRPs-AdipoRs-AMPK/PPARα axes
por: Guo, Chengcheng, et al.
Publicado: (2022)

Native adiponectin in serum binds to mammalian cells expressing T-cadherin, but not AdipoRs or calreticulin
por: Kita, Shunbun, et al.
Publicado: (2019)

A monoclonal antibody activating AdipoR for type 2 diabetes and nonalcoholic steatohepatitis
por: Asahara, Naomi, et al.
Publicado: (2023)

Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer's disease neuropathological deficits
por: Shah, S A, et al.
Publicado: (2017)

Corrigendum to: Adiponectin Inhibits Lipopolysaccharide-Induced Adventitial Fibroblast Migration and Transition to Myofibroblasts via AdipoR1-AMPK-iNOS Pathway
Publicado: (2022)

PEG-BHD1028 Peptide Regulates Insulin Resistance and Fatty Acid β-Oxidation, and Mitochondrial Biogenesis by Binding to Two Heterogeneous Binding Sites of Adiponectin Receptors, AdipoR1 and AdipoR2
por: Lee, In Kyung, et al.
Publicado: (2021)

Inhibition of ceramide accumulation in AdipoR1(–/–) mice increases photoreceptor survival and improves vision
por: Lewandowski, Dominik, et al.
Publicado: (2022)

Synergistic activation of AMPK by AdipoR1/2 agonist and inhibitor of EDPs–EBP interaction recover NAFLD through enhancing mitochondrial function in mice
por: Song, Nazi, et al.
Publicado: (2023)

Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity
por: Okada-Iwabu, Miki, et al.
Publicado: (2015)

Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons
por: Li, Chen, et al.
Publicado: (2020)

Discovery of a transdermally deliverable pentapeptide for activating AdipoR1 to promote hair growth
por: Ohn, Jungyoon, et al.
Publicado: (2021)

Adiponectin/AdipoR1 Axis Promotes IL-10 Release by Human Regulatory T Cells
por: Ramos-Ramírez, Patricia, et al.
Publicado: (2021)

AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity
por: Ruiz, Mario, et al.
Publicado: (2023)

Activation of AdipoR1 with rCTRP9 Preserves BBB Integrity through the APPL1/AMPK/Nrf2 Signaling Pathway in ICH Mice
por: Zhao, Wei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_22j8r6hau64kvgpn3cje2o56nq