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The prion protein is not required for peripheral nerve de- and remyelination after crush injury

The cellular prion protein (PrP) is essential to the long-term maintenance of myelin sheaths in peripheral nerves. PrP activates the adhesion G-protein coupled receptor Adgrg6 on Schwann cells and initiates a pro-myelination cascade of molecular signals. Because Adgrg6 is crucial for peripheral myel...

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Detalles Bibliográficos
Autores principales: Henzi, Anna, Aguzzi, Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822300/
https://www.ncbi.nlm.nih.gov/pubmed/33481951
http://dx.doi.org/10.1371/journal.pone.0245944
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author Henzi, Anna
Aguzzi, Adriano
author_facet Henzi, Anna
Aguzzi, Adriano
author_sort Henzi, Anna
collection PubMed
description The cellular prion protein (PrP) is essential to the long-term maintenance of myelin sheaths in peripheral nerves. PrP activates the adhesion G-protein coupled receptor Adgrg6 on Schwann cells and initiates a pro-myelination cascade of molecular signals. Because Adgrg6 is crucial for peripheral myelin development and regeneration after nerve injury, we investigated the role of PrP in peripheral nerve repair. We performed experimental sciatic nerve crush injuries in co-isogenic wild-type and PrP-deficient mice, and examined peripheral nerve repair processes. Generation of repair Schwann cells, macrophage recruitment and remyelination were similar in PrP-deficient and wild-type mice. We conclude that PrP is dispensable for sciatic nerve de- and remyelination after crush injury. Adgrg6 may sustain its function in peripheral nerve repair independently of its activation by PrP.
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spelling pubmed-78223002021-01-29 The prion protein is not required for peripheral nerve de- and remyelination after crush injury Henzi, Anna Aguzzi, Adriano PLoS One Research Article The cellular prion protein (PrP) is essential to the long-term maintenance of myelin sheaths in peripheral nerves. PrP activates the adhesion G-protein coupled receptor Adgrg6 on Schwann cells and initiates a pro-myelination cascade of molecular signals. Because Adgrg6 is crucial for peripheral myelin development and regeneration after nerve injury, we investigated the role of PrP in peripheral nerve repair. We performed experimental sciatic nerve crush injuries in co-isogenic wild-type and PrP-deficient mice, and examined peripheral nerve repair processes. Generation of repair Schwann cells, macrophage recruitment and remyelination were similar in PrP-deficient and wild-type mice. We conclude that PrP is dispensable for sciatic nerve de- and remyelination after crush injury. Adgrg6 may sustain its function in peripheral nerve repair independently of its activation by PrP. Public Library of Science 2021-01-22 /pmc/articles/PMC7822300/ /pubmed/33481951 http://dx.doi.org/10.1371/journal.pone.0245944 Text en © 2021 Henzi, Aguzzi http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Henzi, Anna
Aguzzi, Adriano
The prion protein is not required for peripheral nerve de- and remyelination after crush injury
title The prion protein is not required for peripheral nerve de- and remyelination after crush injury
title_full The prion protein is not required for peripheral nerve de- and remyelination after crush injury
title_fullStr The prion protein is not required for peripheral nerve de- and remyelination after crush injury
title_full_unstemmed The prion protein is not required for peripheral nerve de- and remyelination after crush injury
title_short The prion protein is not required for peripheral nerve de- and remyelination after crush injury
title_sort prion protein is not required for peripheral nerve de- and remyelination after crush injury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822300/
https://www.ncbi.nlm.nih.gov/pubmed/33481951
http://dx.doi.org/10.1371/journal.pone.0245944
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