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Drug use for gastrointestinal symptoms during pregnancy: A French nationwide study 2010–2018

PURPOSE: To describe drug prescription for gastrointestinal symptoms during pregnancy. METHODS: Using the French national health database, we identified pregnancies ending with a birth between April 2010 and December 2018, in France. We studied prescription of antacids, antispasmodics, antinauseants...

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Autores principales: Meyer, Antoine, Fermaut, Marion, Drouin, Jérôme, Carbonnel, Franck, Weill, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822332/
https://www.ncbi.nlm.nih.gov/pubmed/33481904
http://dx.doi.org/10.1371/journal.pone.0245854
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author Meyer, Antoine
Fermaut, Marion
Drouin, Jérôme
Carbonnel, Franck
Weill, Alain
author_facet Meyer, Antoine
Fermaut, Marion
Drouin, Jérôme
Carbonnel, Franck
Weill, Alain
author_sort Meyer, Antoine
collection PubMed
description PURPOSE: To describe drug prescription for gastrointestinal symptoms during pregnancy. METHODS: Using the French national health database, we identified pregnancies ending with a birth between April 2010 and December 2018, in France. We studied prescription of antacids, antispasmodics, antinauseants, laxatives and antidiarrheals during pregnancy, between two trimesters before and two trimesters after delivery. We also assessed hospitalization for gastrointestinal symptoms during pregnancy. RESULTS: Among 6,365,471 pregnancies, 4,452,779 (74.0%) received at least one gastrointestinal drug during pregnancy; 2,228,275 (37.0%) received an antacid, 3,096,858 (51.5%) an antispasmodic, 1,861,731 (31.0%) an antinauseant, 919,116 (15.3%) a laxative and 617,808 (10.3%) an antidiarrheal. Prescription of proton pump inhibitors doubled from 12.2% in 2010 to 26.0% in 2018, while domperidone use decreased from 18.3% in 2010 to 2.2% in 2018. In addition, prescription of antacids increased from 7.0% during the trimester before pregnancy to 11.8% during the 1(st) trimester, 17.0% during the 2(nd) trimester and 23.4% during the 3(rd) trimester. Antispasmodic use was 10.6% during the trimester before pregnancy, 23.1% during the 1(st) trimester, 25.2% during the 2(nd) trimester and 24.0% during the 3(rd) trimester. Prescription of antinauseant drugs increased from 5.0% during the trimester before pregnancy to 25.7% during the 1(st) trimester, then decreased to 6.4% during the 2(nd) trimester and 3.2% during the 3(rd) trimester. Nausea/vomiting was the most common cause of hospitalization for gastrointestinal symptoms or diseases during pregnancy, although it accounted for only 1.0% of pregnancies. CONCLUSIONS: Approximately three-quarters of women use drugs for gastrointestinal symptoms during pregnancy in France. Prescription of gastrointestinal drugs during pregnancy should be the subject of more detailed risk-benefit assessment and recommendations.
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spelling pubmed-78223322021-01-29 Drug use for gastrointestinal symptoms during pregnancy: A French nationwide study 2010–2018 Meyer, Antoine Fermaut, Marion Drouin, Jérôme Carbonnel, Franck Weill, Alain PLoS One Research Article PURPOSE: To describe drug prescription for gastrointestinal symptoms during pregnancy. METHODS: Using the French national health database, we identified pregnancies ending with a birth between April 2010 and December 2018, in France. We studied prescription of antacids, antispasmodics, antinauseants, laxatives and antidiarrheals during pregnancy, between two trimesters before and two trimesters after delivery. We also assessed hospitalization for gastrointestinal symptoms during pregnancy. RESULTS: Among 6,365,471 pregnancies, 4,452,779 (74.0%) received at least one gastrointestinal drug during pregnancy; 2,228,275 (37.0%) received an antacid, 3,096,858 (51.5%) an antispasmodic, 1,861,731 (31.0%) an antinauseant, 919,116 (15.3%) a laxative and 617,808 (10.3%) an antidiarrheal. Prescription of proton pump inhibitors doubled from 12.2% in 2010 to 26.0% in 2018, while domperidone use decreased from 18.3% in 2010 to 2.2% in 2018. In addition, prescription of antacids increased from 7.0% during the trimester before pregnancy to 11.8% during the 1(st) trimester, 17.0% during the 2(nd) trimester and 23.4% during the 3(rd) trimester. Antispasmodic use was 10.6% during the trimester before pregnancy, 23.1% during the 1(st) trimester, 25.2% during the 2(nd) trimester and 24.0% during the 3(rd) trimester. Prescription of antinauseant drugs increased from 5.0% during the trimester before pregnancy to 25.7% during the 1(st) trimester, then decreased to 6.4% during the 2(nd) trimester and 3.2% during the 3(rd) trimester. Nausea/vomiting was the most common cause of hospitalization for gastrointestinal symptoms or diseases during pregnancy, although it accounted for only 1.0% of pregnancies. CONCLUSIONS: Approximately three-quarters of women use drugs for gastrointestinal symptoms during pregnancy in France. Prescription of gastrointestinal drugs during pregnancy should be the subject of more detailed risk-benefit assessment and recommendations. Public Library of Science 2021-01-22 /pmc/articles/PMC7822332/ /pubmed/33481904 http://dx.doi.org/10.1371/journal.pone.0245854 Text en © 2021 Meyer et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Meyer, Antoine
Fermaut, Marion
Drouin, Jérôme
Carbonnel, Franck
Weill, Alain
Drug use for gastrointestinal symptoms during pregnancy: A French nationwide study 2010–2018
title Drug use for gastrointestinal symptoms during pregnancy: A French nationwide study 2010–2018
title_full Drug use for gastrointestinal symptoms during pregnancy: A French nationwide study 2010–2018
title_fullStr Drug use for gastrointestinal symptoms during pregnancy: A French nationwide study 2010–2018
title_full_unstemmed Drug use for gastrointestinal symptoms during pregnancy: A French nationwide study 2010–2018
title_short Drug use for gastrointestinal symptoms during pregnancy: A French nationwide study 2010–2018
title_sort drug use for gastrointestinal symptoms during pregnancy: a french nationwide study 2010–2018
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822332/
https://www.ncbi.nlm.nih.gov/pubmed/33481904
http://dx.doi.org/10.1371/journal.pone.0245854
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