Pseudouridines of tRNA Anticodon Stem-Loop Have Unexpected Role in Mutagenesis in Pseudomonas sp.

Pseudouridines are known to be important for optimal translation. In this study we demonstrate an unexpected link between pseudouridylation of tRNA and mutation frequency in Pseudomonas species. We observed that the lack of pseudouridylation activity of pseudouridine synthases TruA or RluA elevates...

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Detalles Bibliográficos
Autores principales: Tagel, Mari, Ilves, Heili, Leppik, Margus, Jürgenstein, Karl, Remme, Jaanus, Kivisaar, Maia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822408/
https://www.ncbi.nlm.nih.gov/pubmed/33374637
http://dx.doi.org/10.3390/microorganisms9010025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822408/
https://www.ncbi.nlm.nih.gov/pubmed/33374637
http://dx.doi.org/10.3390/microorganisms9010025

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