A 33-mRNA Classifier Is Able to Produce Inflammopathic, Adaptive, and Coagulopathic Endotypes with Prognostic Significance: The Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis (ORANGES) Trial

Background: Retrospective analysis of the transcriptomic host response in sepsis has demonstrated that sepsis can be separated into three endotypes—inflammatory (IE), adaptive (AE), and coagulopathic (CE), which have demonstrated prognostic significance. We undertook a prospective transcriptomic hos...

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Detalles Bibliográficos
Autores principales: Iglesias, Jose, Vassallo, Andrew V., Liesenfeld, Oliver, Levine, Jerrold S., Patel, Vishal V., Sullivan, Jesse B., Cavanaugh, Joseph B., Elbaga, Yasmine, Sweeney, Timothy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822486/
https://www.ncbi.nlm.nih.gov/pubmed/33374697
http://dx.doi.org/10.3390/jpm11010009

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