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Point of Care Diagnostics in the Age of COVID-19

The recent outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated serious respiratory disease, coronavirus disease 2019 (COVID-19), poses a major threat to global public health. Owing to the lack of vaccine and effective treatments, many countries have been o...

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Autores principales: Rezaei, Meysam, Razavi Bazaz, Sajad, Zhand, Sareh, Sayyadi, Nima, Jin, Dayong, Stewart, Martin P., Ebrahimi Warkiani, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822494/
https://www.ncbi.nlm.nih.gov/pubmed/33374612
http://dx.doi.org/10.3390/diagnostics11010009
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author Rezaei, Meysam
Razavi Bazaz, Sajad
Zhand, Sareh
Sayyadi, Nima
Jin, Dayong
Stewart, Martin P.
Ebrahimi Warkiani, Majid
author_facet Rezaei, Meysam
Razavi Bazaz, Sajad
Zhand, Sareh
Sayyadi, Nima
Jin, Dayong
Stewart, Martin P.
Ebrahimi Warkiani, Majid
author_sort Rezaei, Meysam
collection PubMed
description The recent outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated serious respiratory disease, coronavirus disease 2019 (COVID-19), poses a major threat to global public health. Owing to the lack of vaccine and effective treatments, many countries have been overwhelmed with an exponential spread of the virus and surge in the number of confirmed COVID-19 cases. Current standard diagnostic methods are inadequate for widespread testing as they suffer from prolonged turn-around times (>12 h) and mostly rely on high-biosafety-level laboratories and well-trained technicians. Point-of-care (POC) tests have the potential to vastly improve healthcare in several ways, ranging from enabling earlier detection and easier monitoring of disease to reaching remote populations. In recent years, the field of POC diagnostics has improved markedly with the advent of micro- and nanotechnologies. Due to the COVID-19 pandemic, POC technologies have been rapidly innovated to address key limitations faced in existing standard diagnostic methods. This review summarizes and compares the latest available POC immunoassay, nucleic acid-based and clustered regularly interspaced short palindromic repeats- (CRISPR)-mediated tests for SARS-CoV-2 detection that we anticipate aiding healthcare facilities to control virus infection and prevent subsequent spread.
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spelling pubmed-78224942021-01-23 Point of Care Diagnostics in the Age of COVID-19 Rezaei, Meysam Razavi Bazaz, Sajad Zhand, Sareh Sayyadi, Nima Jin, Dayong Stewart, Martin P. Ebrahimi Warkiani, Majid Diagnostics (Basel) Review The recent outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated serious respiratory disease, coronavirus disease 2019 (COVID-19), poses a major threat to global public health. Owing to the lack of vaccine and effective treatments, many countries have been overwhelmed with an exponential spread of the virus and surge in the number of confirmed COVID-19 cases. Current standard diagnostic methods are inadequate for widespread testing as they suffer from prolonged turn-around times (>12 h) and mostly rely on high-biosafety-level laboratories and well-trained technicians. Point-of-care (POC) tests have the potential to vastly improve healthcare in several ways, ranging from enabling earlier detection and easier monitoring of disease to reaching remote populations. In recent years, the field of POC diagnostics has improved markedly with the advent of micro- and nanotechnologies. Due to the COVID-19 pandemic, POC technologies have been rapidly innovated to address key limitations faced in existing standard diagnostic methods. This review summarizes and compares the latest available POC immunoassay, nucleic acid-based and clustered regularly interspaced short palindromic repeats- (CRISPR)-mediated tests for SARS-CoV-2 detection that we anticipate aiding healthcare facilities to control virus infection and prevent subsequent spread. MDPI 2020-12-23 /pmc/articles/PMC7822494/ /pubmed/33374612 http://dx.doi.org/10.3390/diagnostics11010009 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rezaei, Meysam
Razavi Bazaz, Sajad
Zhand, Sareh
Sayyadi, Nima
Jin, Dayong
Stewart, Martin P.
Ebrahimi Warkiani, Majid
Point of Care Diagnostics in the Age of COVID-19
title Point of Care Diagnostics in the Age of COVID-19
title_full Point of Care Diagnostics in the Age of COVID-19
title_fullStr Point of Care Diagnostics in the Age of COVID-19
title_full_unstemmed Point of Care Diagnostics in the Age of COVID-19
title_short Point of Care Diagnostics in the Age of COVID-19
title_sort point of care diagnostics in the age of covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822494/
https://www.ncbi.nlm.nih.gov/pubmed/33374612
http://dx.doi.org/10.3390/diagnostics11010009
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