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Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients

Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONM...

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Autores principales: Quintairos, Luis, Colom, Helena, Millán, Olga, Fortuna, Virginia, Espinosa, Cristina, Guirado, Lluis, Budde, Klemens, Sommerer, Claudia, Lizana, Ana, López-Púa, Yolanda, Brunet, Mercè
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822507/
https://www.ncbi.nlm.nih.gov/pubmed/33481955
http://dx.doi.org/10.1371/journal.pone.0245880
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author Quintairos, Luis
Colom, Helena
Millán, Olga
Fortuna, Virginia
Espinosa, Cristina
Guirado, Lluis
Budde, Klemens
Sommerer, Claudia
Lizana, Ana
López-Púa, Yolanda
Brunet, Mercè
author_facet Quintairos, Luis
Colom, Helena
Millán, Olga
Fortuna, Virginia
Espinosa, Cristina
Guirado, Lluis
Budde, Klemens
Sommerer, Claudia
Lizana, Ana
López-Púa, Yolanda
Brunet, Mercè
author_sort Quintairos, Luis
collection PubMed
description Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONMEM to quantify the relationships of miR155-5p urinary expression, CXCL-10 urinary concentration and tacrolimus and mycophenolic acid (MPA) exposure with the probability of AR in adult kidney transplant patients during the early post-transplant period. Owing to the contribution of therapeutic drug monitoring to achieving target exposure, neither tacrolimus nor MPA cumulative exposure was identified as a predictor of AR in the studied population. Even though CXCL-10 urinary concentration showed a trend, its effect on AR was not significant. In contrast, urinary miR155-5p expression was prognostic of clinical outcome. Monitoring miR155-5p urinary pellet expression together with immunosuppressive drug exposure could be very useful during routine clinical practice to identify patients with a potential high risk of rejection at the early stages of the post-transplant period. This early risk assessment would allow for the optimization of treatment and improved prevention of AR.
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spelling pubmed-78225072021-01-29 Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients Quintairos, Luis Colom, Helena Millán, Olga Fortuna, Virginia Espinosa, Cristina Guirado, Lluis Budde, Klemens Sommerer, Claudia Lizana, Ana López-Púa, Yolanda Brunet, Mercè PLoS One Research Article Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONMEM to quantify the relationships of miR155-5p urinary expression, CXCL-10 urinary concentration and tacrolimus and mycophenolic acid (MPA) exposure with the probability of AR in adult kidney transplant patients during the early post-transplant period. Owing to the contribution of therapeutic drug monitoring to achieving target exposure, neither tacrolimus nor MPA cumulative exposure was identified as a predictor of AR in the studied population. Even though CXCL-10 urinary concentration showed a trend, its effect on AR was not significant. In contrast, urinary miR155-5p expression was prognostic of clinical outcome. Monitoring miR155-5p urinary pellet expression together with immunosuppressive drug exposure could be very useful during routine clinical practice to identify patients with a potential high risk of rejection at the early stages of the post-transplant period. This early risk assessment would allow for the optimization of treatment and improved prevention of AR. Public Library of Science 2021-01-22 /pmc/articles/PMC7822507/ /pubmed/33481955 http://dx.doi.org/10.1371/journal.pone.0245880 Text en © 2021 Quintairos et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Quintairos, Luis
Colom, Helena
Millán, Olga
Fortuna, Virginia
Espinosa, Cristina
Guirado, Lluis
Budde, Klemens
Sommerer, Claudia
Lizana, Ana
López-Púa, Yolanda
Brunet, Mercè
Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients
title Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients
title_full Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients
title_fullStr Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients
title_full_unstemmed Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients
title_short Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients
title_sort early prognostic performance of mir155-5p monitoring for the risk of rejection: logistic regression with a population pharmacokinetic approach in adult kidney transplant patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822507/
https://www.ncbi.nlm.nih.gov/pubmed/33481955
http://dx.doi.org/10.1371/journal.pone.0245880
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