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Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis
Interaction between adult stem cells and their progeny is critical for tissue homeostasis and regeneration. In multiple organs, mesenchymal stem cells (MSCs) give rise to transit amplifying cells (TACs), which then differentiate into different cell types. However, whether and how MSCs interact with...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822593/ https://www.ncbi.nlm.nih.gov/pubmed/33480845 http://dx.doi.org/10.7554/eLife.59459 |
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author | Jing, Junjun Feng, Jifan Li, Jingyuan Zhao, Hu Ho, Thach-Vu He, Jinzhi Yuan, Yuan Guo, Tingwei Du, Jiahui Urata, Mark Sharpe, Paul Chai, Yang |
author_facet | Jing, Junjun Feng, Jifan Li, Jingyuan Zhao, Hu Ho, Thach-Vu He, Jinzhi Yuan, Yuan Guo, Tingwei Du, Jiahui Urata, Mark Sharpe, Paul Chai, Yang |
author_sort | Jing, Junjun |
collection | PubMed |
description | Interaction between adult stem cells and their progeny is critical for tissue homeostasis and regeneration. In multiple organs, mesenchymal stem cells (MSCs) give rise to transit amplifying cells (TACs), which then differentiate into different cell types. However, whether and how MSCs interact with TACs remains unknown. Using the adult mouse incisor as a model, we present in vivo evidence that TACs and MSCs have distinct genetic programs and engage in reciprocal signaling cross talk to maintain tissue homeostasis. Specifically, an IGF-WNT signaling cascade is involved in the feedforward from MSCs to TACs. TACs are regulated by tissue-autonomous canonical WNT signaling and can feedback to MSCs and regulate MSC maintenance via Wnt5a/Ror2-mediated non-canonical WNT signaling. Collectively, these findings highlight the importance of coordinated bidirectional signaling interaction between MSCs and TACs in instructing mesenchymal tissue homeostasis, and the mechanisms identified here have important implications for MSC–TAC interaction in other organs. |
format | Online Article Text |
id | pubmed-7822593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-78225932021-01-25 Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis Jing, Junjun Feng, Jifan Li, Jingyuan Zhao, Hu Ho, Thach-Vu He, Jinzhi Yuan, Yuan Guo, Tingwei Du, Jiahui Urata, Mark Sharpe, Paul Chai, Yang eLife Developmental Biology Interaction between adult stem cells and their progeny is critical for tissue homeostasis and regeneration. In multiple organs, mesenchymal stem cells (MSCs) give rise to transit amplifying cells (TACs), which then differentiate into different cell types. However, whether and how MSCs interact with TACs remains unknown. Using the adult mouse incisor as a model, we present in vivo evidence that TACs and MSCs have distinct genetic programs and engage in reciprocal signaling cross talk to maintain tissue homeostasis. Specifically, an IGF-WNT signaling cascade is involved in the feedforward from MSCs to TACs. TACs are regulated by tissue-autonomous canonical WNT signaling and can feedback to MSCs and regulate MSC maintenance via Wnt5a/Ror2-mediated non-canonical WNT signaling. Collectively, these findings highlight the importance of coordinated bidirectional signaling interaction between MSCs and TACs in instructing mesenchymal tissue homeostasis, and the mechanisms identified here have important implications for MSC–TAC interaction in other organs. eLife Sciences Publications, Ltd 2021-01-22 /pmc/articles/PMC7822593/ /pubmed/33480845 http://dx.doi.org/10.7554/eLife.59459 Text en © 2021, Jing et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology Jing, Junjun Feng, Jifan Li, Jingyuan Zhao, Hu Ho, Thach-Vu He, Jinzhi Yuan, Yuan Guo, Tingwei Du, Jiahui Urata, Mark Sharpe, Paul Chai, Yang Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis |
title | Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis |
title_full | Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis |
title_fullStr | Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis |
title_full_unstemmed | Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis |
title_short | Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis |
title_sort | reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822593/ https://www.ncbi.nlm.nih.gov/pubmed/33480845 http://dx.doi.org/10.7554/eLife.59459 |
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