Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design

The macrodomain of nsP3 (nsP3MD) is highly conserved among the alphaviruses and ADP-ribosylhydrolase activity of Chikungunya Virus (CHIKV) nsP3MD is critical for CHIKV viral replication and virulence. No small molecule drugs targeting CHIKV nsP3 have been identified to date. Here we report small fra...

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Detalles Bibliográficos
Autores principales: Zhang, Sixue, Garzan, Atefeh, Haese, Nicole, Bostwick, Robert, Martinez-Gzegozewska, Yohanka, Rasmussen, Lynn, Streblow, Daniel N., Haise, Mark T., Pathak, Ashish K., Augelli-Szafran, Corinne E., Wu, Mousheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822648/
https://www.ncbi.nlm.nih.gov/pubmed/33482665
http://dx.doi.org/10.1371/journal.pone.0245013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822648/
https://www.ncbi.nlm.nih.gov/pubmed/33482665
http://dx.doi.org/10.1371/journal.pone.0245013

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