Cargando…

Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design

The macrodomain of nsP3 (nsP3MD) is highly conserved among the alphaviruses and ADP-ribosylhydrolase activity of Chikungunya Virus (CHIKV) nsP3MD is critical for CHIKV viral replication and virulence. No small molecule drugs targeting CHIKV nsP3 have been identified to date. Here we report small fra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Sixue, Garzan, Atefeh, Haese, Nicole, Bostwick, Robert, Martinez-Gzegozewska, Yohanka, Rasmussen, Lynn, Streblow, Daniel N., Haise, Mark T., Pathak, Ashish K., Augelli-Szafran, Corinne E., Wu, Mousheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822648/ https://www.ncbi.nlm.nih.gov/pubmed/33482665 http://dx.doi.org/10.1371/journal.pone.0245013

Ejemplares similares

Cell-Type-Dependent Role for nsP3 Macrodomain ADP-Ribose Binding and Hydrolase Activity during Chikungunya Virus Infection
por: Kim, Taewoo, et al.
Publicado: (2022)

Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice
por: Abraham, Rachy, et al.
Publicado: (2020)

Chikungunya virus nsP1 interacts directly with nsP2 and modulates its ATPase activity
por: Kumar, Sameer, et al.
Publicado: (2018)

Expression and biochemical characterization of nsP2 cysteine protease of Chikungunya virus
por: Pastorino, Boris A.M., et al.
Publicado: (2008)

Mosquito Rasputin interacts with chikungunya virus nsP3 and determines the infection rate in Aedes albopictus
por: Fros, Jelke J., et al.
Publicado: (2015)

Analysis of chikungunya virus proteins reveals that non-structural proteins nsP2 and nsP3 exhibit RNA interference (RNAi) suppressor activity
por: Mathur, Kalika, et al.
Publicado: (2016)

NTPase and 5′-RNA Triphosphatase Activities of Chikungunya Virus nsP2 Protein
por: Karpe, Yogesh A., et al.
Publicado: (2011)

Discovery of in silico hits targeting the nsP3 macro domain of chikungunya virus
por: Nguyen, Phuong T. V., et al.
Publicado: (2014)

1,3-Thiazolbenzamide Derivatives as Chikungunya Virus nsP2 Protease Inhibitors
por: Ivanova, Larisa, et al.
Publicado: (2021)

Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain
por: Sherrill, Lavinia M., et al.
Publicado: (2022)

Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors
por: Schuller, Marion, et al.
Publicado: (2023)

Conserved motifs in the hypervariable domain of chikungunya virus nsP3 required for transmission by Aedes aegypti mosquitoes
por: Göertz, Giel P., et al.
Publicado: (2018)

A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding
por: Wu, Mousheng, et al.
Publicado: (2018)

Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists
por: Tanguturi, Parthasaradhireddy, et al.
Publicado: (2021)

Correction: Tanguturi et al. Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists. Molecules 2021, 26, 6693
por: Tanguturi, Parthasaradhireddy, et al.
Publicado: (2022)

Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores
por: Jones, Rhian, et al.
Publicado: (2023)

Full length and protease domain activity of chikungunya virus nsP2 differ from other alphavirus nsP2 proteases in recognition of small peptide substrates
por: Saisawang, Chonticha, et al.
Publicado: (2015)

Molecular Modeling and Docking Study to Elucidate Novel Chikungunya Virus nsP2 Protease Inhibitors
por: Agarwal, T., et al.
Publicado: (2015)

The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection
por: Delang, L., et al.
Publicado: (2016)

Evaluation of the Antiviral Potential of Halogenated Dihydrorugosaflavonoids and Molecular Modeling with nsP3 Protein of Chikungunya Virus (CHIKV)
por: Puranik, Ninad V., et al.
Publicado: (2019)

Insights into the role of the cobalt(III)-thiosemicarbazone complex as a potential inhibitor of the Chikungunya virus nsP4
por: Martins, Daniel Oliveira Silva, et al.
Publicado: (2022)

Nonhuman Primate Models of Chikungunya Virus Infection and Disease (CHIKV NHP Model)
por: Broeckel, Rebecca, et al.
Publicado: (2015)

A Sensitive and Robust High-Throughput Screening Assay for Inhibitors of the Chikungunya Virus nsP1 Capping Enzyme
por: Bullard-Feibelman, Kristen M., et al.
Publicado: (2016)

Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication
por: Krieg, Sarah, et al.
Publicado: (2023)

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
por: Schuller, Marion, et al.
Publicado: (2021)

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking
por: Schuller, Marion, et al.
Publicado: (2020)

Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness
por: Mounce, Bryan C., et al.
Publicado: (2017)

Targeted in vitro gene silencing of E2 and nsP1 genes of chikungunya virus by biocompatible zeolitic imidazolate framework
por: Tagore, Rajarshee, et al.
Publicado: (2022)

Sindbis Virus nsP2 Endopeptidase
por: Strauss, Ellen G., et al.
Publicado: (2013)

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2
por: Gahbauer, Stefan, et al.
Publicado: (2022)

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2
por: Gahbauer, Stefan, et al.
Publicado: (2023)

Expression of Plasmid-Based shRNA against the E1 and nsP1 Genes Effectively Silenced Chikungunya Virus Replication
por: Lam, Shirley, et al.
Publicado: (2012)

Chikungunya nsP2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine
por: Saisawang, Chonticha, et al.
Publicado: (2015)

Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation
por: Rathore, Abhay P S, et al.
Publicado: (2013)

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue
por: Rausalu, Kai, et al.
Publicado: (2016)

Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virus
por: Saha, Amrita, et al.
Publicado: (2018)

An Unexpected Deamination Reaction after Hydrolysis of the Pyrimidine (6-4) Pyrimidone Photoproduct
por: Lin, Gengjie, et al.
Publicado: (2014)

Facile construction of substituted pyrimido[4,5-d]pyrimidones by transformation of enaminouracil
por: Hamama, Wafaa S., et al.
Publicado: (2012)

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature
por: Correy, Galen J., et al.
Publicado: (2022)

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature
por: Correy, Galen J., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_28ctp89imavvava4qdafio70cq