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Roles of Bile-Derived Exosomes in Hepatobiliary Disease

Exosomes are vesicles with a diameter of 30-150 nm produced by living cells and secreted into the extracellular matrix. Exosomes mediate cellular communication by carrying active molecules, such as nucleic acids, proteins, and liposomes. Although exosomes are found in various body fluids, little is...

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Detalles Bibliográficos
Autores principales: Yao, Yuan, Jiao, Dechao, Li, Zhaonan, Zhou, Xueliang, Li, Jing, Liu, Zaoqu, Han, Xinwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822672/
https://www.ncbi.nlm.nih.gov/pubmed/33511212
http://dx.doi.org/10.1155/2021/8743409
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author Yao, Yuan
Jiao, Dechao
Li, Zhaonan
Zhou, Xueliang
Li, Jing
Liu, Zaoqu
Han, Xinwei
author_facet Yao, Yuan
Jiao, Dechao
Li, Zhaonan
Zhou, Xueliang
Li, Jing
Liu, Zaoqu
Han, Xinwei
author_sort Yao, Yuan
collection PubMed
description Exosomes are vesicles with a diameter of 30-150 nm produced by living cells and secreted into the extracellular matrix. Exosomes mediate cellular communication by carrying active molecules, such as nucleic acids, proteins, and liposomes. Although exosomes are found in various body fluids, little is known about bile-derived exosomes. This review is the first to summarize the methods of bile storage and isolation of biliary exosomes, highlighting the roles of bile-derived exosomes, especially exosomal noncoding RNAs, in physiological and disease states and discussing their potential clinical applications.
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spelling pubmed-78226722021-01-27 Roles of Bile-Derived Exosomes in Hepatobiliary Disease Yao, Yuan Jiao, Dechao Li, Zhaonan Zhou, Xueliang Li, Jing Liu, Zaoqu Han, Xinwei Biomed Res Int Review Article Exosomes are vesicles with a diameter of 30-150 nm produced by living cells and secreted into the extracellular matrix. Exosomes mediate cellular communication by carrying active molecules, such as nucleic acids, proteins, and liposomes. Although exosomes are found in various body fluids, little is known about bile-derived exosomes. This review is the first to summarize the methods of bile storage and isolation of biliary exosomes, highlighting the roles of bile-derived exosomes, especially exosomal noncoding RNAs, in physiological and disease states and discussing their potential clinical applications. Hindawi 2021-01-13 /pmc/articles/PMC7822672/ /pubmed/33511212 http://dx.doi.org/10.1155/2021/8743409 Text en Copyright © 2021 Yuan Yao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yao, Yuan
Jiao, Dechao
Li, Zhaonan
Zhou, Xueliang
Li, Jing
Liu, Zaoqu
Han, Xinwei
Roles of Bile-Derived Exosomes in Hepatobiliary Disease
title Roles of Bile-Derived Exosomes in Hepatobiliary Disease
title_full Roles of Bile-Derived Exosomes in Hepatobiliary Disease
title_fullStr Roles of Bile-Derived Exosomes in Hepatobiliary Disease
title_full_unstemmed Roles of Bile-Derived Exosomes in Hepatobiliary Disease
title_short Roles of Bile-Derived Exosomes in Hepatobiliary Disease
title_sort roles of bile-derived exosomes in hepatobiliary disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822672/
https://www.ncbi.nlm.nih.gov/pubmed/33511212
http://dx.doi.org/10.1155/2021/8743409
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