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Roles of Bile-Derived Exosomes in Hepatobiliary Disease
Exosomes are vesicles with a diameter of 30-150 nm produced by living cells and secreted into the extracellular matrix. Exosomes mediate cellular communication by carrying active molecules, such as nucleic acids, proteins, and liposomes. Although exosomes are found in various body fluids, little is...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822672/ https://www.ncbi.nlm.nih.gov/pubmed/33511212 http://dx.doi.org/10.1155/2021/8743409 |
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author | Yao, Yuan Jiao, Dechao Li, Zhaonan Zhou, Xueliang Li, Jing Liu, Zaoqu Han, Xinwei |
author_facet | Yao, Yuan Jiao, Dechao Li, Zhaonan Zhou, Xueliang Li, Jing Liu, Zaoqu Han, Xinwei |
author_sort | Yao, Yuan |
collection | PubMed |
description | Exosomes are vesicles with a diameter of 30-150 nm produced by living cells and secreted into the extracellular matrix. Exosomes mediate cellular communication by carrying active molecules, such as nucleic acids, proteins, and liposomes. Although exosomes are found in various body fluids, little is known about bile-derived exosomes. This review is the first to summarize the methods of bile storage and isolation of biliary exosomes, highlighting the roles of bile-derived exosomes, especially exosomal noncoding RNAs, in physiological and disease states and discussing their potential clinical applications. |
format | Online Article Text |
id | pubmed-7822672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-78226722021-01-27 Roles of Bile-Derived Exosomes in Hepatobiliary Disease Yao, Yuan Jiao, Dechao Li, Zhaonan Zhou, Xueliang Li, Jing Liu, Zaoqu Han, Xinwei Biomed Res Int Review Article Exosomes are vesicles with a diameter of 30-150 nm produced by living cells and secreted into the extracellular matrix. Exosomes mediate cellular communication by carrying active molecules, such as nucleic acids, proteins, and liposomes. Although exosomes are found in various body fluids, little is known about bile-derived exosomes. This review is the first to summarize the methods of bile storage and isolation of biliary exosomes, highlighting the roles of bile-derived exosomes, especially exosomal noncoding RNAs, in physiological and disease states and discussing their potential clinical applications. Hindawi 2021-01-13 /pmc/articles/PMC7822672/ /pubmed/33511212 http://dx.doi.org/10.1155/2021/8743409 Text en Copyright © 2021 Yuan Yao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yao, Yuan Jiao, Dechao Li, Zhaonan Zhou, Xueliang Li, Jing Liu, Zaoqu Han, Xinwei Roles of Bile-Derived Exosomes in Hepatobiliary Disease |
title | Roles of Bile-Derived Exosomes in Hepatobiliary Disease |
title_full | Roles of Bile-Derived Exosomes in Hepatobiliary Disease |
title_fullStr | Roles of Bile-Derived Exosomes in Hepatobiliary Disease |
title_full_unstemmed | Roles of Bile-Derived Exosomes in Hepatobiliary Disease |
title_short | Roles of Bile-Derived Exosomes in Hepatobiliary Disease |
title_sort | roles of bile-derived exosomes in hepatobiliary disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822672/ https://www.ncbi.nlm.nih.gov/pubmed/33511212 http://dx.doi.org/10.1155/2021/8743409 |
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