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Sequential Water and Headgroup Merger: Membrane Poration Paths and Energetics from MD Simulations

Membrane topology changes such as poration, stalk formation, and hemifusion rupture are essential to cellular function, but their molecular details, energetics, and kinetics are still not fully understood. Here, we present a unified energetic and mechanistic picture of metastable pore defects in ten...

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Detalles Bibliográficos
Autores principales: Bubnis, Greg, Grubmüller, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822740/
https://www.ncbi.nlm.nih.gov/pubmed/33189685
http://dx.doi.org/10.1016/j.bpj.2020.10.037

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