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Sequential Water and Headgroup Merger: Membrane Poration Paths and Energetics from MD Simulations
Membrane topology changes such as poration, stalk formation, and hemifusion rupture are essential to cellular function, but their molecular details, energetics, and kinetics are still not fully understood. Here, we present a unified energetic and mechanistic picture of metastable pore defects in ten...
Autores principales: | Bubnis, Greg, Grubmüller, Helmut |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822740/ https://www.ncbi.nlm.nih.gov/pubmed/33189685 http://dx.doi.org/10.1016/j.bpj.2020.10.037 |
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