Cargando…

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

The fusion oncogene RUNX1/RUNX1T1 encodes an aberrant transcription factor, which plays a key role in the initiation and maintenance of acute myeloid leukemia. Here we show that the RUNX1/RUNX1T1 oncogene is a regulator of alternative RNA splicing in leukemic cells. The comprehensive analysis of RUN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grinev, Vasily V., Barneh, Farnaz, Ilyushonak, Ilya M., Nakjang, Sirintra, Smink, Job, van Oort, Anita, Clough, Richard, Seyani, Michael, McNeill, Hesta, Reza, Mojgan, Martinez-Soria, Natalia, Assi, Salam A., Ramanouskaya, Tatsiana V., Bonifer, Constanze, Heidenreich, Olaf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822815/ https://www.ncbi.nlm.nih.gov/pubmed/33483506 http://dx.doi.org/10.1038/s41467-020-20848-z

Ejemplares similares

RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML
por: Loke, Justin, et al.
Publicado: (2017)

RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks
por: Kellaway, Sophie G., et al.
Publicado: (2020)

The RUNX1/RUNX1T1 network: translating insights into therapeutic options
por: Swart, Laura E., et al.
Publicado: (2021)

Nanoparticle-mediated targeting of the fusion gene RUNX1/ETO in t(8;21)-positive acute myeloid leukaemia
por: Issa, Hasan, et al.
Publicado: (2023)

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation
por: Martinez-Soria, Natalia, et al.
Publicado: (2018)

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation
por: Martinez-Soria, Natalia, et al.
Publicado: (2019)

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis
por: Lichtinger, Monika, et al.
Publicado: (2012)

The Co-operation of RUNX1 with LDB1, CDK9 and BRD4 Drives Transcription Factor Complex Relocation During Haematopoietic Specification
por: Gilmour, Jane, et al.
Publicado: (2018)

The leukemia-associated RUNX1/ETO oncoprotein confers a mutator phenotype
por: Forster, V J, et al.
Publicado: (2016)

t(8;21) Acute Myeloid Leukemia as a Paradigm for the Understanding of Leukemogenesis at the Level of Gene Regulation and Chromatin Programming
por: Kellaway, Sophie, et al.
Publicado: (2020)

Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories
por: Kellaway, Sophie G, et al.
Publicado: (2021)

The hematopoietic master regulator RUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
por: Lichtinger, Monika, et al.
Publicado: (2013)

RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1
por: Ponnusamy, K, et al.
Publicado: (2015)

Characterization of RNA aptamers that disrupt the RUNX1–CBFβ/DNA complex
por: Barton, Jenny L., et al.
Publicado: (2009)

RUNX1-ETO (RUNX1-RUNX1T1) induces myeloid leukemia in mice in an age-dependent manner
por: Abdallah, Mohamed Gaber, et al.
Publicado: (2021)

RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction
por: Ptasinska, Anetta, et al.
Publicado: (2019)

RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction
por: Ptasinska, Anetta, et al.
Publicado: (2019)

Prognostic Impacts of D816V KIT Mutation and Peri-Transplant RUNX1–RUNX1T1 MRD Monitoring on Acute Myeloid Leukemia with RUNX1–RUNX1T1
por: Cho, Byung-Sik, et al.
Publicado: (2021)

Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells
por: Nafria, Monica, et al.
Publicado: (2020)

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding
por: Ptasinska, A, et al.
Publicado: (2012)

Runx proteins regulate Foxp3 expression
por: Bruno, Ludovica, et al.
Publicado: (2009)

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers
por: Illendula, Anuradha, et al.
Publicado: (2016)

RUNX1 and breast cancer
por: Mercado-Matos, Jose, et al.
Publicado: (2017)

Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement
por: Tokunaga, Kenji, et al.
Publicado: (2017)

Elucidation of Novel Therapeutic Targets for Acute Myeloid Leukemias with RUNX1-RUNX1T1 Fusion
por: Yun, Jae Won, et al.
Publicado: (2019)

Volunteer unrelated donor cell‐derived acute myeloid leukemia with RUNX1‐RUNX1T1
por: Hagiwara, Shinya, et al.
Publicado: (2021)

Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia
por: Klco, Jeffery, et al.
Publicado: (2023)

Hemophagocytic Lymphohistiocytosis in RUNX1::RUNX1T1 Positive AML with Blast Count Below 20%
por: Huang, Xingqin, et al.
Publicado: (2023)

Thrombospondin-1 Is a Putative Target Gene of Runx2 and Runx3
por: Shi, Xiuming, et al.
Publicado: (2013)

Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia
por: Hornung, Roman, et al.
Publicado: (2018)

Unique N-terminal sequences in two Runx1 isoforms are dispensable for Runx1 function
por: Nieke, Sebastian, et al.
Publicado: (2017)

Pseudo-Chediak-Higashi granules in myeloid cells in therapy-related AML with RUNX1-RUNX1T1
por: Cho, Sung Ran, et al.
Publicado: (2018)

Machine learning derived genomics driven prognostication for acute myeloid leukemia with RUNX1-RUNX1T1
por: Shaikh, Anam Fatima, et al.
Publicado: (2020)

Immunohistochemical Staining to Identify Concomitant Systemic Mastocytosis in Acute Myeloid Leukemia with RUNX1::RUNX1T1
por: Hwang, Sang Mee, et al.
Publicado: (2022)

Transcription Factors Runx1 and Runx3 Suppress Keratin Expression in Undifferentiated Keratinocytes
por: Ogawa, Eisaku, et al.
Publicado: (2022)

Resveratrol Mediated Modulation of Sirt-1/Runx2 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells: Potential Role of Runx2 Deacetylation
por: Shakibaei, Mehdi, et al.
Publicado: (2012)

The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy
por: Homan, Claire C., et al.
Publicado: (2021)

RUNX1T1 function in cell fate
por: Hu, Nan, et al.
Publicado: (2022)

Molecular characterization of AML with RUNX1-RUNX1T1 at diagnosis and relapse reveals net loss of co-mutations
por: Höllein, Alexander, et al.
Publicado: (2019)

RUNX1 as a recombinase cofactor
por: Cieslak, Agata, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ooioi7movg6rg0j2lnkegjaefv