Discovery of a new class of integrin antibodies for fibrosis

Lung fibrosis, or the scarring of the lung, is a devastating disease with huge unmet medical need. There are limited treatment options and its prognosis is worse than most types of cancer. We previously discovered that MK-0429 is an equipotent pan-inhibitor of αv integrins that reduces proteinuria a...

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Detalles Bibliográficos
Autores principales: Zhang, Ji, Wang, Tao, Saigal, Ashmita, Johnson, Josephine, Morrisson, Jennifer, Tabrizifard, Sahba, Hollingsworth, Scott A., Eddins, Michael J., Mao, Wenxian, O’Neill, Kim, Garcia-Calvo, Margarita, Carballo-Jane, Ester, Liu, DingGang, Ham, Taewon, Zhou, Qiong, Dong, Weifeng, Meng, Hsien-Wei, Hicks, Jacqueline, Cai, Tian-Quan, Akiyama, Taro, Pinto, Shirly, Cheng, Alan C., Greshock, Thomas, Marquis, John C., Ren, Zhao, Talukdar, Saswata, Shaheen, Hussam Hisham, Handa, Masahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822819/
https://www.ncbi.nlm.nih.gov/pubmed/33483531
http://dx.doi.org/10.1038/s41598-021-81253-0

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