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CTLA-4 expression by B-1a B cells is essential for immune tolerance

CTLA-4 is an important regulator of T-cell function. Here, we report that expression of this immune-regulator in mouse B-1a cells has a critical function in maintaining self-tolerance by regulating these early-developing B cells that express a repertoire enriched for auto-reactivity. Selective delet...

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Detalles Bibliográficos
Autores principales:	Yang, Yang, Li, Xiao, Ma, Zhihai, Wang, Chunlin, Yang, Qunying, Byrne-Steele, Miranda, Hong, Rongjian, Min, Qing, Zhou, Gao, Cheng, Yong, Qin, Guang, Youngyunpipatkul, Justin V., Wing, James B., Sakaguchi, Shimon, Toonstra, Christian, Wang, Lai-Xi, Vilches-Moure, Jose G., Wang, Denong, Snyder, Michael P., Wang, Ji-Yang, Han, Jian, Herzenberg, Leonore A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822855/ https://www.ncbi.nlm.nih.gov/pubmed/33483505 http://dx.doi.org/10.1038/s41467-020-20874-x

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