Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides

An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excelle...

Descripción completa

Detalles Bibliográficos
Autores principales: Hua, Ting-Bi, Liu, Cheng-Xiong, Hu, Wei-Min, Wang, Long, Yang, Qing-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822858/
https://www.ncbi.nlm.nih.gov/pubmed/33483530
http://dx.doi.org/10.1038/s41598-021-81370-w
_version_ 1783639721211068416
author Hua, Ting-Bi
Liu, Cheng-Xiong
Hu, Wei-Min
Wang, Long
Yang, Qing-Qing
author_facet Hua, Ting-Bi
Liu, Cheng-Xiong
Hu, Wei-Min
Wang, Long
Yang, Qing-Qing
author_sort Hua, Ting-Bi
collection PubMed
description An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields.
format Online
Article
Text
id pubmed-7822858
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-78228582021-01-26 Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides Hua, Ting-Bi Liu, Cheng-Xiong Hu, Wei-Min Wang, Long Yang, Qing-Qing Sci Rep Article An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields. Nature Publishing Group UK 2021-01-22 /pmc/articles/PMC7822858/ /pubmed/33483530 http://dx.doi.org/10.1038/s41598-021-81370-w Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hua, Ting-Bi
Liu, Cheng-Xiong
Hu, Wei-Min
Wang, Long
Yang, Qing-Qing
Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
title Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
title_full Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
title_fullStr Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
title_full_unstemmed Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
title_short Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
title_sort mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822858/
https://www.ncbi.nlm.nih.gov/pubmed/33483530
http://dx.doi.org/10.1038/s41598-021-81370-w
work_keys_str_mv AT huatingbi mildsynthesisofisoxazolinederivativesviaanefficient41annulationreactionoftransientnitrosoalkenesandsulfurylides
AT liuchengxiong mildsynthesisofisoxazolinederivativesviaanefficient41annulationreactionoftransientnitrosoalkenesandsulfurylides
AT huweimin mildsynthesisofisoxazolinederivativesviaanefficient41annulationreactionoftransientnitrosoalkenesandsulfurylides
AT wanglong mildsynthesisofisoxazolinederivativesviaanefficient41annulationreactionoftransientnitrosoalkenesandsulfurylides
AT yangqingqing mildsynthesisofisoxazolinederivativesviaanefficient41annulationreactionoftransientnitrosoalkenesandsulfurylides

Ejemplares similares