The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells

The novel small molecule PTC596 inhibits microtubule polymerization and its clinical development has been initiated for some solid cancers. We herein investigated the preclinical efficacy of PTC596 alone and in combination with proteasome inhibitors in the treatment of multiple myeloma (MM). PTC596...

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Detalles Bibliográficos
Autores principales: Nagai, Yurie, Mimura, Naoya, Rizq, Ola, Isshiki, Yusuke, Oshima, Motohiko, Rizk, Mohamed, Saraya, Atsunori, Koide, Shuhei, Nakajima-Takagi, Yaeko, Miyota, Makiko, Chiba, Tetsuhiro, Oshima-Hasegawa, Nagisa, Muto, Tomoya, Tsukamoto, Shokichi, Mitsukawa, Shio, Takeda, Yusuke, Ohwada, Chikako, Takeuchi, Masahiro, Iseki, Tohru, Nakaseko, Chiaki, Lennox, William, Sheedy, Josephine, Weetall, Marla, Yokote, Koutaro, Iwama, Atsushi, Sakaida, Emiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822878/
https://www.ncbi.nlm.nih.gov/pubmed/33483574
http://dx.doi.org/10.1038/s41598-021-81577-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822878/
https://www.ncbi.nlm.nih.gov/pubmed/33483574
http://dx.doi.org/10.1038/s41598-021-81577-x

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