The relationship between different C-peptide level and insulin dose of insulin pump

BACKGROUND: This study aims to explore the insulin requirement profiles, and analyze the related factors of type-2 diabetes mellitus (T2DM) with different C-peptide levels on insulin pump therapy. METHODS: A retrospective study was conducted on 271 T2DM patients treated with insulin pumps from 2016 to 2018. These patients were divided into groups according to the ratio of C-peptide at 2 h after meals to fasting C-peptide (C(2)h/C(0)), and the dosage of insulin and influencing factors were analyzed. RESULTS: In comparing group A (C(2h)/C(0) < 2.5) with group B (C(2h)/C(0) ≥ 2.5), the percentage of the base amount in total (%TBa, 0.50 ± 0.06) in group A was higher than that in group B (0.48 ± 0.05) (P < 0.05). Furthermore, there was a correlation between C(2h)/C(0) and waist circumference, HbA1c, Fasting Plasma Glucose (FPG) and Blood glucose 2 h after meal (2hPG) (r = −0.137, −0.154, −0.471, and −0.172; all, P < 0.05). The multiple linear regression analysis revealed that BMI and FPG were independent factors of %TBa (β′ = 0.124 and 0.144; all, P < 0.05), and BMI and FPG were independent factors of C(2h)/C(0) (β′ = −0.134 and −0.502; all, P < 0.05). CONCLUSIONS: The basal premeal dose ratio of T2DM with different C-peptide levels differs during intensive insulin pump therapy. Parameters that indicate the glycemic control and β-cell function should be taken into consideration for total insulin requirements.