A directional 3D neurite outgrowth model for studying motor axon biology and disease

We report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a microfluidic platform. Neurons extend their axons into an adjacent layer of gel, whereas dendrites and soma remain predominan...

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Detalles Bibliográficos
Autores principales: Spijkers, Xandor M., Pasteuning-Vuhman, Svetlana, Dorleijn, Jennifa C., Vulto, Paul, Wevers, Nienke R., Pasterkamp, R. Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822896/
https://www.ncbi.nlm.nih.gov/pubmed/33483540
http://dx.doi.org/10.1038/s41598-021-81335-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822896/
https://www.ncbi.nlm.nih.gov/pubmed/33483540
http://dx.doi.org/10.1038/s41598-021-81335-z

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